Linked Life Data

16720944

Source:http://linkedlifedata.com/resource/pubmed/id/16720944

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-5-24
pubmed:abstractText
The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or "statins", are used as cholesterol-lowering agents worldwide. This review, focused on recent experimental and clinical data, summarizes general mechanisms of statin actions underlying neuroprotective effects in the central nervous system (CNS) and presents evidence for putative mechanisms involving heat shock proteins and the survival-related PI-3K/Akt pathway that may be beneficial for the treatment of neurological disorders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0922-6028
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
79-95
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Statin-mediated protective effects in the central nervous system: general mechanisms and putative role of stress proteins.
pubmed:affiliation
Department of Neurology, Neuroregeneration Laboratory, University of Jena Medical School, Jena, Germany. christian.schmeer@med.uni-jena.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't