| pubmed-article:1672038 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1672038 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:1672038 | lifeskim:mentions | umls-concept:C0680022 | lld:lifeskim |
| pubmed-article:1672038 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:1672038 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:1672038 | lifeskim:mentions | umls-concept:C0011164 | lld:lifeskim |
| pubmed-article:1672038 | lifeskim:mentions | umls-concept:C1513776 | lld:lifeskim |
| pubmed-article:1672038 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:1672038 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1672038 | pubmed:issue | 6310 | lld:pubmed |
| pubmed-article:1672038 | pubmed:dateCreated | 1991-4-9 | lld:pubmed |
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| pubmed-article:1672038 | pubmed:abstractText | Three dominant mutations of mec-4, a gene needed for mechanosensation, cause the touch-receptor neurons of Caenorhabditis elegans to degenerate. With deg-1, another C. elegans gene that can mutate to induce neuronal degeneration and that is similar in sequence, mec-4 defines a new gene family. Cross-hybridizing sequences are detectable in other species, raising the possibility that degenerative conditions in other organisms may be caused by mutations in similar genes. All three dominant mec-4 mutations affect the same amino acid. Effects of amino-acid substitutions at this position suggest that steric hindrance may induce the degenerative state. | lld:pubmed |
| pubmed-article:1672038 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1672038 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1672038 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1672038 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1672038 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1672038 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1672038 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:1672038 | pubmed:author | pubmed-author:ChalfinDD | lld:pubmed |
| pubmed-article:1672038 | pubmed:author | pubmed-author:DriscollMM | lld:pubmed |
| pubmed-article:1672038 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1672038 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:1672038 | pubmed:volume | 349 | lld:pubmed |
| pubmed-article:1672038 | pubmed:geneSymbol | mec-6 | lld:pubmed |
| pubmed-article:1672038 | pubmed:geneSymbol | deg-1 | lld:pubmed |
| pubmed-article:1672038 | pubmed:geneSymbol | mec-4 | lld:pubmed |
| pubmed-article:1672038 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1672038 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1672038 | pubmed:pagination | 588-93 | lld:pubmed |
| pubmed-article:1672038 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1672038 | pubmed:meshHeading | pubmed-meshheading:1672038-... | lld:pubmed |
| pubmed-article:1672038 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1672038 | pubmed:articleTitle | The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration. | lld:pubmed |
| pubmed-article:1672038 | pubmed:affiliation | Department of Biological Sciences, Columbia University, New York, New York 10027. | lld:pubmed |
| pubmed-article:1672038 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1672038 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1672038 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1672038 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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