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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6310
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pubmed:dateCreated |
1991-4-9
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pubmed:databankReference |
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pubmed:abstractText |
Three dominant mutations of mec-4, a gene needed for mechanosensation, cause the touch-receptor neurons of Caenorhabditis elegans to degenerate. With deg-1, another C. elegans gene that can mutate to induce neuronal degeneration and that is similar in sequence, mec-4 defines a new gene family. Cross-hybridizing sequences are detectable in other species, raising the possibility that degenerative conditions in other organisms may be caused by mutations in similar genes. All three dominant mec-4 mutations affect the same amino acid. Effects of amino-acid substitutions at this position suggest that steric hindrance may induce the degenerative state.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
349
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pubmed:geneSymbol |
deg-1,
mec-4,
mec-6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
588-93
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1672038-Amino Acid Sequence,
pubmed-meshheading:1672038-Animals,
pubmed-meshheading:1672038-Base Sequence,
pubmed-meshheading:1672038-Caenorhabditis,
pubmed-meshheading:1672038-Chromosome Mapping,
pubmed-meshheading:1672038-Cloning, Molecular,
pubmed-meshheading:1672038-Genes,
pubmed-meshheading:1672038-Genetic Complementation Test,
pubmed-meshheading:1672038-Mechanoreceptors,
pubmed-meshheading:1672038-Molecular Sequence Data,
pubmed-meshheading:1672038-Multigene Family,
pubmed-meshheading:1672038-Mutation,
pubmed-meshheading:1672038-Nerve Degeneration,
pubmed-meshheading:1672038-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:1672038-Restriction Mapping,
pubmed-meshheading:1672038-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1672038-Touch
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pubmed:year |
1991
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pubmed:articleTitle |
The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration.
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pubmed:affiliation |
Department of Biological Sciences, Columbia University, New York, New York 10027.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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