Source:http://linkedlifedata.com/resource/pubmed/id/16720380
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2006-5-24
|
| pubmed:abstractText |
Brain arteriovenous malformations (BAVM) have high matrix metalloproteinase-9 (MMP-9) expression, the source of which is unclear. We hypothesized MMP-9 production might be due to inflammation in BAVM. Compared to control brain tissues (n = 5), BAVM tissue (n = 139) had a higher expression (by ELISA) of myeloperoxidase (MPO) (193 +/- 189 vs. 6 +/- 3, ng/mg, P < .001), MMP-9 (28 +/- 32 vs. 0.7 +/- 0.6, ng/mg, P < .001), and IL-6 (102 +/- 218 vs. 0.1 +/- 0.1, pg/mg, P < .001), but not eNOS (114 +/- 87 vs. 65 +/- 9, pg/mg, P = .09). MMP-9 expression in BAVM highly correlated with myeloperoxidase (R2 = .76, P < .001), as well as with IL-6 (R2 = .32, P < .001). In contrast, MMP-9 in BAVM poorly correlated with the endothelial marker, eNOS (R2 = .03, P = .05), and CD31 (R2 = .004, P = .57). Compared to non-embolized patients (n = 46), patients with pre-operative embolization (n = 93) had higher levels of myeloperoxidase (236 +/- 205 vs. 106 +/- 108, ng/mg, P < .001) and MMP-9 (33 +/- 35 vs. 16 +/- 20, ng/mg, P < .001), however the correlation between MMP-9 and myeloperoxidase was equally strong for both groups (R2 = .69, n = 93, P < .001, for both). MMP-9 expression correlated with the lipocalin-MMP-9 complex, suggesting neutrophils as the MMP-9 source. MPO co-localized with majority of MMP-9 signal by immunohistochemistry. Our data suggest that inflammation is a prominent feature of BAVM lesional phenotype, and neutrophils appear to be a major source of MMP-9 in these lesions.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD31,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/NOS3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxidase
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1093-4715
|
| pubmed:author |
pubmed-author:AchrolAchal SAS,
pubmed-author:BarbaroNicholas MNM,
pubmed-author:BollenAndrew WAW,
pubmed-author:ChenYongmeiY,
pubmed-author:FanYongfengY,
pubmed-author:HashimotoTomokiT,
pubmed-author:LawtonMichael TMT,
pubmed-author:LeeChanhungC,
pubmed-author:McCullochCharles ECE,
pubmed-author:PoonK Y TrudyKY,
pubmed-author:YangGuo-YuanGY,
pubmed-author:YoungWilliam LWL,
pubmed-author:ZhuYiqianY
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3121-8
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:16720380-Adult,
pubmed-meshheading:16720380-Antigens, CD31,
pubmed-meshheading:16720380-Biological Markers,
pubmed-meshheading:16720380-Case-Control Studies,
pubmed-meshheading:16720380-Embolization, Therapeutic,
pubmed-meshheading:16720380-Endothelial Cells,
pubmed-meshheading:16720380-Female,
pubmed-meshheading:16720380-Humans,
pubmed-meshheading:16720380-Inflammation,
pubmed-meshheading:16720380-Interleukin-6,
pubmed-meshheading:16720380-Intracranial Arteriovenous Malformations,
pubmed-meshheading:16720380-Leukocytes,
pubmed-meshheading:16720380-Male,
pubmed-meshheading:16720380-Matrix Metalloproteinase 9,
pubmed-meshheading:16720380-Neutrophils,
pubmed-meshheading:16720380-Nitric Oxide Synthase Type III,
pubmed-meshheading:16720380-Peroxidase,
pubmed-meshheading:16720380-Prospective Studies
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations.
|
| pubmed:affiliation |
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
|