Linked Life Data

16718364

Source:http://linkedlifedata.com/resource/pubmed/id/16718364

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2006-9-26
pubmed:databankReference
pubmed:abstractText
BTB/POZ protein family plays a key role in many biological processes both in Drosophila and vertebrates through regulating the transcriptional activities of some downstream genes. Here, we obtained a novel member of human BTB/POZ protein family, named as ZBTB34 (Zinc finger and BTB domain containing 34), which encodes 504 amino acid residues with a BTB/POZ domain at its N-terminus that is similar to the same domain of other known transcription regulators. RT-PCR analysis indicated that ZBTB34 was expressed ubiquitously in most adult human tissues, and whilst immunofluorescence assays showed that ZBTB34 was mainly localized to nucleus. Interestingly, the reporter assay in mammalian cells suggested that ZBTB34 might function as a transcriptional repressor. This present work as the first report about the functional exploration of the novel ZBTB34 gene would be contributed to profound understanding of the transcriptional regulation via BTB/POZ protein family.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0300-8177
pubmed:author
pubmed:issnType
Print
pubmed:volume
290
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
159-67
pubmed:dateRevised
2007-5-4
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
ZBTB34, a novel human BTB/POZ zinc finger protein, is a potential transcriptional repressor.
pubmed:affiliation
Institute Biochemistry and Molecular Biology, School of Bioengineering, East China University of Science and Technology, Shanghai 200237, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't