Linked Life Data

16716546

Source:http://linkedlifedata.com/resource/pubmed/id/16716546

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-8-28
pubmed:abstractText
Total rhubarb anthraquinones (TRAs) are the active therapeutic components from the rhizomes of Rheum palmatum L. (Polygonaceae), which are widely used in traditional Chinese medicines (TCMs) and have been reported to have cell toxicity recently. This study focuses on the toxicity of TRAs on Sprague Dawley (S.D.) rats. TRAs administrated per os for 13 weeks induced nephrotoxicity on S.D. rats as renal tubule epithelial cells swelled and denatured in tissue slice examination. After high-density oligonucleotide microarrays scanning, we have identified mitogen-activated protein kinase (MAPK) kinase 6 to be the target gene which causes cell cycle arrest and proliferation inhibition and contributes to nephrotoxicity on S.D. rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0378-8741
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
308-11
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays.
pubmed:affiliation
National Drug Screening Laboratory, China Pharmaceutical University, No. 1 ShenNong Road, E-04#, Nanjing City, 210038 Jiangsu Province, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't