Linked Life Data

16716524

Source:http://linkedlifedata.com/resource/pubmed/id/16716524

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-7-24
pubmed:abstractText
Huntington's disease is a fatal neurodegenerative disorder caused by a mutation of the huntingtin gene and involves progressive motor abnormalities (including chorea), cognitive deficits (dementia) as well as psychiatric symptoms. We have previously demonstrated that environmental enrichment slows the onset and progression of Huntington's disease in transgenic mice. Here, we investigated the effects of enhanced physical exercise on disease progression and brain-derived neurotrophic factor expression. Standard-housed Huntington's disease mice developed phenotypic rear-paw clasping by 16 weeks of age, displayed abnormal rearing behavior, deficits in motor co-ordination and of spatial working memory. Huntington's disease mice with access to running wheels exhibited delayed onset of rear-paw clasping, normalized levels of rearing behavior and amelioration of the cognitive deficits. However, in contrast to our previous environmental enrichment studies, there was no rescue of motor coordination deficits in wheel-running Huntington's disease mice. An abnormal accumulation of brain-derived neurotrophic factor protein in the frontal cortex of Huntington's disease mice was unaffected by running. Striatal and hippocampal brain-derived neurotrophic factor protein levels were unchanged. Brain-derived neurotrophic factor mRNA levels were reduced in the anterior cortex, striatum and hippocampus of Huntington's disease mice, and only striatal deficits were ameliorated by running. Overall, we show that voluntary physical exercise delays the onset of Huntington's disease and the decline in cognitive ability. In addition, our results reveal that some aspects of hippocampal dependent memory are not entirely reliant on sustained hippocampal brain-derived neurotrophic factor expression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
141
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
569-84
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16716524-Age Factors, pubmed-meshheading:16716524-Analysis of Variance, pubmed-meshheading:16716524-Animals, pubmed-meshheading:16716524-Behavior, Animal, pubmed-meshheading:16716524-Brain-Derived Neurotrophic Factor, pubmed-meshheading:16716524-Corpus Striatum, pubmed-meshheading:16716524-Disease Models, Animal, pubmed-meshheading:16716524-Exploratory Behavior, pubmed-meshheading:16716524-Frontal Lobe, pubmed-meshheading:16716524-Gene Expression Regulation, pubmed-meshheading:16716524-Huntington Disease, pubmed-meshheading:16716524-Male, pubmed-meshheading:16716524-Maze Learning, pubmed-meshheading:16716524-Mice, pubmed-meshheading:16716524-Mice, Transgenic, pubmed-meshheading:16716524-Nerve Tissue Proteins, pubmed-meshheading:16716524-Nuclear Proteins, pubmed-meshheading:16716524-Physical Conditioning, Animal, pubmed-meshheading:16716524-Psychomotor Performance, pubmed-meshheading:16716524-RNA, Messenger, pubmed-meshheading:16716524-Reaction Time, pubmed-meshheading:16716524-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:16716524-Running, pubmed-meshheading:16716524-Time Factors
pubmed:year
2006
pubmed:articleTitle
Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice.
pubmed:affiliation
Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia. t.pang@hfi.unimelb.edu.au
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't