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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1991-3-20
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pubmed:abstractText |
RP 56976 (taxotere), a new semisynthetic analogue of taxol, is a potentially important chemotherapeutic agent for the treatment of cancer. We report here that this drug is a potent inhibitor of cell replication and, like taxol, promotes the in vitro assembly of stable microtubules in the absence of guanosine triphosphate and induces microtubule-bundle formation in cells. Compared with taxol, RP 56976 is slightly more active as a promoter of tubulin polymerization. As an inhibitor of cell replication, RP 56976 is 2.5-fold more potent than taxol in J774.2 and P388 cells and at least 5-fold more potent in taxol-resistant cells.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
pubmed:issn |
0027-8874
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
288-91
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1671606-Alkaloids,
pubmed-meshheading:1671606-Animals,
pubmed-meshheading:1671606-Cell Survival,
pubmed-meshheading:1671606-Cells, Cultured,
pubmed-meshheading:1671606-Cricetinae,
pubmed-meshheading:1671606-Cricetulus,
pubmed-meshheading:1671606-Guanosine Triphosphate,
pubmed-meshheading:1671606-Leukemia, Lymphoid,
pubmed-meshheading:1671606-Microtubules,
pubmed-meshheading:1671606-Paclitaxel,
pubmed-meshheading:1671606-Structure-Activity Relationship,
pubmed-meshheading:1671606-Taxoids,
pubmed-meshheading:1671606-Tumor Cells, Cultured
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pubmed:year |
1991
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pubmed:articleTitle |
Studies with RP 56976 (taxotere): a semisynthetic analogue of taxol.
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pubmed:affiliation |
Department of Pharmacology, Hadassah Medical School, Hebrew University, Jerusalem, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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