Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1 Pt 2
|
| pubmed:dateCreated |
1991-3-12
|
| pubmed:abstractText |
We investigated serial changes in myocardial norepinephrine content and myocardial adrenergic receptors during the development of cardiomyopathy in Syrian hamsters (Bio 14.6) and their age-matched healthy controls. We also examined phosphatidylinositide hydrolysis after alpha 1-adrenergic stimulation and the effects of alpha 1-blockade. We found that in the prehypertrophic stage, myocardial norepinephrine content and densities of alpha 1- and beta-adrenergic receptors were significantly higher in the cardiomyopathic hamsters than in the controls. However, in the early heart failure stage, beta-receptor density was 28% lower than that of the age-matched controls, although alpha 1-receptor density remained 55% higher. Norepinephrine-stimulated phosphatidylinositide hydrolysis in the cardiomyopathic hamster in the hypertrophic stage was twice that in the controls, indicating that the increase in alpha 1-adrenergic receptors is coupled with the intracellular signal transduction. Furthermore, selective alpha 1-adrenoceptor blockade by bunazosin in the cardiomyopathic hamsters from 70 to 170 days of age reduced myocardial hypertrophy and focal myocardial necrosis. Thus we conclude that increased alpha 1-adrenergic activity plays an important role in progression of cardiac hypertrophy is cardiomyopathic Syrian hamsters.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositols,
http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/bunazosin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0002-9513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
260
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
H80-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1671540-Adrenergic alpha-Antagonists,
pubmed-meshheading:1671540-Animals,
pubmed-meshheading:1671540-Calcium Channels,
pubmed-meshheading:1671540-Cardiomegaly,
pubmed-meshheading:1671540-Cardiomyopathies,
pubmed-meshheading:1671540-Cricetinae,
pubmed-meshheading:1671540-Dose-Response Relationship, Drug,
pubmed-meshheading:1671540-Heart,
pubmed-meshheading:1671540-Hydrolysis,
pubmed-meshheading:1671540-Mesocricetus,
pubmed-meshheading:1671540-Myocardium,
pubmed-meshheading:1671540-Norepinephrine,
pubmed-meshheading:1671540-Organ Size,
pubmed-meshheading:1671540-Phosphatidylinositols,
pubmed-meshheading:1671540-Quinazolines,
pubmed-meshheading:1671540-Receptors, Adrenergic, alpha,
pubmed-meshheading:1671540-Receptors, Adrenergic, beta,
pubmed-meshheading:1671540-Signal Transduction
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Role of increased alpha 1-adrenergic activity in cardiomyopathic Syrian hamster.
|
| pubmed:affiliation |
First Department of Medicine, Osaka University Medical School Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|