Source:http://linkedlifedata.com/resource/pubmed/id/16715205
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2007-2-26
|
| pubmed:abstractText |
In idiopathic Parkinson's disease (PD), a tremor-dominant type (TDT), an akinetic-rigid type (ART), and a mixed type (MT) are distinguished. We compared cerebral [I-123]FP-CIT SPECT in the PD subtypes (67 patients Hoehn and Yahr stage 1:26 with ART, 19 with MT, 22 with TDT). We measured the ratios putamen/occipital lobe binding and caudate nucleus/occipital lobe binding. Parkinsonian motor symptoms were quantified by UPDRS motor scale. In both putamen and caudate nucleus contralateral to the clinically affected body side TDT patients showed a significantly higher FP-CIT uptake than ART or MT patients (ANOVA; p<0.01). Contralateral putamen and caudate nucleus FP-CIT uptake correlated significantly with severity of rigidity (p<0.01) and hypokinesia (p<0.01) but not with severity of resting or postural tremor (p>0.05). The missing correlation between striatal FP-CIT uptake and tremor suggests, that further systems besides the nigrostriatal dopaminergic system may contribute to generation of parkinsonian tremor.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0300-9564
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
114
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
331-5
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| pubmed:meshHeading |
pubmed-meshheading:16715205-Adult,
pubmed-meshheading:16715205-Age of Onset,
pubmed-meshheading:16715205-Aged,
pubmed-meshheading:16715205-Binding, Competitive,
pubmed-meshheading:16715205-Caudate Nucleus,
pubmed-meshheading:16715205-Corpus Striatum,
pubmed-meshheading:16715205-Diagnosis, Differential,
pubmed-meshheading:16715205-Disease Progression,
pubmed-meshheading:16715205-Dopamine,
pubmed-meshheading:16715205-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:16715205-Female,
pubmed-meshheading:16715205-Humans,
pubmed-meshheading:16715205-Male,
pubmed-meshheading:16715205-Middle Aged,
pubmed-meshheading:16715205-Muscle Rigidity,
pubmed-meshheading:16715205-Occipital Lobe,
pubmed-meshheading:16715205-Parkinson Disease,
pubmed-meshheading:16715205-Predictive Value of Tests,
pubmed-meshheading:16715205-Putamen,
pubmed-meshheading:16715205-Substantia Nigra,
pubmed-meshheading:16715205-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:16715205-Tremor,
pubmed-meshheading:16715205-Tropanes
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Striatal FP-CIT uptake differs in the subtypes of early Parkinson's disease.
|
| pubmed:affiliation |
Department of Neurology, Saarland University, Homburg/Saar, Germany.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|