Linked Life Data

16714058

Source:http://linkedlifedata.com/resource/pubmed/id/16714058

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
26
pubmed:dateCreated
2006-6-5
pubmed:abstractText
Alginate (AL)-whey protein isolate (WPI) microspheres of varied WPI/AL ratio, particle diameter and concentration of polymer bead forming solution (C(AL+WPI)) were prepared in order to develop a biocompatible vehicle for oral administration of bioactive compounds. Microscopy revealed a special matrix/granular structure for microspheres with a WPI/AL ratio of 8:2, 100 microm diameter and C(AL+WPI) of 5% (AL-WPI A2), featuring WPI granules 3-10 microm in diameter homogeneously distributed within an AL spherical matrix. The compound release properties of these microspheres were investigated in simulated gastric and intestinal fluids (SGF and SIF). They demonstrated the desirable property of retarding riboflavin release in SGF and underwent alginate matrix erosion together with liberation of WPI granules in SIF, followed by complete release of the riboflavin. Riboflavin release in SGF and in SIF without pancreatin followed the Higuchi diffusion model while release in SIF in the presence of pancreatin was attributed to WPI granule degradation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0142-9612
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4646-54
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Alginate-whey protein granular microspheres as oral delivery vehicles for bioactive compounds.
pubmed:affiliation
Institut de recherche sur les nutraceutiques et les aliments fonctionnels (INAF/STELA), Faculté des sciences de l'agriculture et de l'alimentation, Université Laval, Pavillon Paul Comtois, Sainte-Foy, Qué., Canada G1K 7P4.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't