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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2006-5-22
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pubmed:abstractText |
The TOR (target of rapamycin) ser/thr protein kinase is the central component of a eukaryotic signaling pathway that regulates growth and is the direct target of the clinically useful drug rapamycin. Recent efforts have identified at least two multiprotein complexes that contain TOR, but little is known in higher eukaryotes about the genes downstream of TOR that control growth.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
958-70
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16713952-Animals,
pubmed-meshheading:16713952-Antibiotics, Antineoplastic,
pubmed-meshheading:16713952-Cell Division,
pubmed-meshheading:16713952-Cell Enlargement,
pubmed-meshheading:16713952-Cell Growth Processes,
pubmed-meshheading:16713952-Cell Line,
pubmed-meshheading:16713952-Down-Regulation,
pubmed-meshheading:16713952-Drosophila,
pubmed-meshheading:16713952-Drosophila Proteins,
pubmed-meshheading:16713952-Gene Expression Profiling,
pubmed-meshheading:16713952-Genes, Developmental,
pubmed-meshheading:16713952-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:16713952-Protein Kinases,
pubmed-meshheading:16713952-RNA Interference,
pubmed-meshheading:16713952-Ribosomes,
pubmed-meshheading:16713952-Sirolimus,
pubmed-meshheading:16713952-Transcription Factors,
pubmed-meshheading:16713952-Up-Regulation
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pubmed:year |
2006
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|
pubmed:articleTitle |
Functional genomics identifies TOR-regulated genes that control growth and division.
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pubmed:affiliation |
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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