Source:http://linkedlifedata.com/resource/pubmed/id/16713606
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2006-7-21
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| pubmed:abstractText |
N-methyl-D-aspartate (NMDA) receptors are widely involved in opioid tolerance. However, it is less clear whether NMDA receptor antagonists reverse already-established tolerance and whether the intensity of the nociceptive stimulus influences morphine tolerance. Three days after implantation of morphine or control pellets the effects of i.v. morphine and pre-administration of saline or (+)-HA966 (a glycine site-specific NMDA receptor antagonist), were studied on the C-fibre reflex elicited by a wide range of stimulus intensities. Morphine both increased the threshold and decreased the slope of the recruitment curve in the "non-tolerant" group of animals. In the "morphine-tolerant" group, the threshold did not change but the gain of the stimulus-response curve decreased. The expression of tolerance to morphine depended on the intensity of the stimulus, being maximal when threshold stimulus intensities were used but considerably less with supra-threshold stimulation. As expected, a single treatment with (+)-HA966, potentiated morphine antinociception in "non-tolerant" rats. However, in "morphine-tolerant" rats (+)-HA966 reversed established morphine tolerance and increased the antinociceptive effects of morphine. These results suggest that (+)-HA966 interfered with expression of morphine tolerance, and offered an encouraging therapeutic approach for pain management in opioid abusers.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/HA 966,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidinones,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0028-3908
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
51
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
191-202
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| pubmed:meshHeading |
pubmed-meshheading:16713606-Analgesics, Opioid,
pubmed-meshheading:16713606-Animals,
pubmed-meshheading:16713606-Blood Pressure,
pubmed-meshheading:16713606-Drug Tolerance,
pubmed-meshheading:16713606-Electric Stimulation,
pubmed-meshheading:16713606-Heart Rate,
pubmed-meshheading:16713606-Injections, Intravenous,
pubmed-meshheading:16713606-Male,
pubmed-meshheading:16713606-Morphine,
pubmed-meshheading:16713606-Nerve Fibers, Unmyelinated,
pubmed-meshheading:16713606-Pain,
pubmed-meshheading:16713606-Pain Threshold,
pubmed-meshheading:16713606-Pyrrolidinones,
pubmed-meshheading:16713606-Rats,
pubmed-meshheading:16713606-Rats, Sprague-Dawley,
pubmed-meshheading:16713606-Receptors, Glycine,
pubmed-meshheading:16713606-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:16713606-Reflex,
pubmed-meshheading:16713606-Stereoisomerism,
pubmed-meshheading:16713606-Sural Nerve
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| pubmed:year |
2006
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| pubmed:articleTitle |
Tolerance to morphine analgesia: evidence for stimulus intensity as a key factor and complete reversal by a glycine site-specific NMDA antagonist.
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| pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale (INSERM) U-713, 75013 Paris, France.
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| pubmed:publicationType |
Journal Article
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