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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-3-14
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pubmed:abstractText |
The T cell-specific transmembrane glycoprotein CD4 interacts with class II MHC molecules via its external domain and is associated with tyrosine kinase p56lck via a cysteine motif in its cytoplasmic domain. We have assessed the ability of CD4 to synergize with the antigen-specific T cell receptor (TCR) for induction of transmembrane signals that result in lymphokine production. Mutant CD4 molecules were introduced into T cells that lacked endogenous CD4 but expressed TCRs specific for lysozyme peptides or the superantigen SEA bound to Ab or Abm12 class II MHC molecules. With either ligand, T cell activation occurred only when CD4 was associated with p56lck. These results demonstrate that residues within the cytoplasmic domain of CD4 are required for its coreceptor function in TCR-mediated signal transduction and strongly support the notion that the association of CD4 with p56lck is critical in this process.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Specific Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
511-20
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1671341-Amino Acid Sequence,
pubmed-meshheading:1671341-Animals,
pubmed-meshheading:1671341-Antigens, CD,
pubmed-meshheading:1671341-Antigens, CD4,
pubmed-meshheading:1671341-Antigens, CD8,
pubmed-meshheading:1671341-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1671341-CD4-Positive T-Lymphocytes,
pubmed-meshheading:1671341-DNA Mutational Analysis,
pubmed-meshheading:1671341-Endocytosis,
pubmed-meshheading:1671341-Lymphocyte Activation,
pubmed-meshheading:1671341-Lymphocyte Specific Protein Tyrosine Kinase p56(lck),
pubmed-meshheading:1671341-Macromolecular Substances,
pubmed-meshheading:1671341-Mice,
pubmed-meshheading:1671341-Molecular Sequence Data,
pubmed-meshheading:1671341-Protein-Tyrosine Kinases,
pubmed-meshheading:1671341-Receptors, Antigen, T-Cell,
pubmed-meshheading:1671341-Signal Transduction,
pubmed-meshheading:1671341-Transfection
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pubmed:year |
1991
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pubmed:articleTitle |
Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells.
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pubmed:affiliation |
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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