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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2006-5-29
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pubmed:abstractText |
A novel triptolide derivative (5R)-5-hydroxytriptolide (LLDT-8) has been shown to have potent immunosuppressive activities. Here LLDT-8 was evaluated in experimental autoimmune encephalomyelitis (EAE), the model of multiple sclerosis (MS). LLDT-8 reduced the incidence and severity of EAE, which was associated with the inhibition of the MOG 35-55 lymphocyte recall response, anti-MOG 35-55 T cell responses, interleukin (IL)-2 and interferon (IFN)-gamma production. In vitro, LLDT-8 inhibited primary T cells proliferation, division, IL-2 and IFN-gamma production stimulated with anti-CD3/28. These findings highlight the fact that LLDT-8 prevents EAE by suppressing T cell proliferation and activation, with a potential for treatment of MS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0165-5728
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pubmed:author |
pubmed-author:DongJia-RongJR,
pubmed-author:FuYun-FengYF,
pubmed-author:HePei-LanPL,
pubmed-author:LiYuan-ChaoYC,
pubmed-author:QuL QLQ,
pubmed-author:SIUG HGH,
pubmed-author:TangWeiW,
pubmed-author:YangYi-FuYF,
pubmed-author:YuZhouZ,
pubmed-author:ZhongXiang-GenXG,
pubmed-author:ZhouRuR,
pubmed-author:ZhuYi-NaYN,
pubmed-author:ZuoJian-PingJP
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pubmed:issnType |
Print
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pubmed:volume |
175
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
142-51
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16712960-Amino Acid Sequence,
pubmed-meshheading:16712960-Animals,
pubmed-meshheading:16712960-Cell Proliferation,
pubmed-meshheading:16712960-Diterpenes,
pubmed-meshheading:16712960-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:16712960-Epoxy Compounds,
pubmed-meshheading:16712960-Female,
pubmed-meshheading:16712960-Immunosuppressive Agents,
pubmed-meshheading:16712960-Lymphocyte Activation,
pubmed-meshheading:16712960-Mice,
pubmed-meshheading:16712960-Mice, Inbred C57BL,
pubmed-meshheading:16712960-Molecular Sequence Data,
pubmed-meshheading:16712960-Phenanthrenes,
pubmed-meshheading:16712960-T-Lymphocytes
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pubmed:year |
2006
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pubmed:articleTitle |
(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation.
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pubmed:affiliation |
Laboratories of Immunopharmacology and Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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