Linked Life Data

16710701

Source:http://linkedlifedata.com/resource/pubmed/id/16710701

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-1-31
pubmed:abstractText
In the human genome, the five adenosine triphosphate (ATP)-binding cassette (ABC) half transporters ABCB2 (TAP1), ABCB3 (TAP2), ABCB9 (TAP-like), and in part, also ABCB8 and ABCB10 are closely related with regard to their structural and functional properties. Although targeted to different cellular compartments such as the endoplasmic reticulum (ER), lysosomes, and mitochondria, they are involved in intracellular peptide trafficking across membranes. The transporter associated with antigen processing (TAP1 and TAP2) constitute a key machinery in the major histocompatibility complex (MHC) class I-mediated cellular immune defense against infected or malignantly transformed cells. TAP translocates the cellular "peptidome" derived primarily from cytosolic proteasomal degradation into the ER lumen for presentation by MHC class I molecules. The homodimeric ABCB9 (TAP-like) complex located in lysosomal compartments shares structural and functional similarities to TAP; however, its biological role seems to be different from the MHC I antigen processing. ABCB8 and ABCB10 are targeted to the inner mitochondrial membrane. MDL1, the yeast homologue of ABCB10, is involved in the export of peptides derived from proteolysis of inner-membrane proteins into the intermembrane space. As such peptides are presented as minor histocompatibility antigens on the surface of mammalian cells, a physiological role of ABCB10 in the antigen processing can be accounted.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/ABCB10 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/ABCB9 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/ATP binding cassette transporter 1, http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters, http://linkedlifedata.com/resource/pubmed/chemical/ICP47 protein, Herpes simplex virus, http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins, http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/TAP1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/TAP2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/US6 protein, Human cytomegalovirus, http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
453
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
591-600
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Intracellular peptide transporters in human--compartmentalization of the "peptidome".
pubmed:affiliation
Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Frankfurt, Germany.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't