Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-6-2
pubmed:abstractText
Identification of specific gene expression signatures characteristic of oncogenic pathways is an important step toward molecular classification of human malignancies. Aberrant activation of the Met signaling pathway is frequently associated with tumor progression and metastasis. In this study, we defined the Met-dependent gene expression signature using global gene expression profiling of WT and Met-deficient primary mouse hepatocytes. Newly identified transcriptional targets of the Met pathway included genes involved in the regulation of oxidative stress responses as well as cell motility, cytoskeletal organization, and angiogenesis. To assess the importance of a Met-regulated gene expression signature, a comparative functional genomic approach was applied to 242 human hepatocellular carcinomas (HCCs) and 7 metastatic liver lesions. Cluster analysis revealed that a subset of human HCCs and all liver metastases shared the Met-induced expression signature. Furthermore, the presence of the Met signature showed significant correlation with increased vascular invasion rate and microvessel density as well as with decreased mean survival time of HCC patients. We conclude that the genetically defined gene expression signatures in combination with comparative functional genomics constitute an attractive paradigm for defining both the function of oncogenic pathways and the clinically relevant subgroups of human cancers.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-10022119, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-10463591, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-10690527, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-10722725, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-11013233, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-11114738, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-11280777, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-11479227, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-11544480, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-11864613, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-11950878, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-11972351, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-12058060, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-12198496, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-12556532, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-12600310, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-12640447, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-12648972, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-12650608, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-12670907, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-12754511, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-12807734, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-12884908, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-14504135, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-14605882, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-14668818, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-14685170, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-14709339, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-14999683, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15068665, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15070743, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15123705, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15150131, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15184677, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15274358, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15349819, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15349906, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15451055, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15459662, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15501463, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15519281, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15565109, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15569684, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15579908, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15608639, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15918143, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15920528, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15920529, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15949770, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-15965925, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-16138117, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-16532004, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-17275125, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-7651534, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-7854452, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-8630075, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-9082986, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-9096589, http://linkedlifedata.com/resource/pubmed/commentcorrection/16710476-9930873
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1582-95
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
More...