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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-2-22
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pubmed:abstractText |
Intravenous injection of 2 x 10(8) DBA/2 spleen cells into adult intact (C57BL/6 x DBA/2) F1 mice results in a stimulatory graft-versus-host reaction (GVHR) linked to the recognition by donor CD4+ T cells of Ia alloantigens on host B cells. In the experiments presented here, we found that this GVHR is associated with a major increase in IgE serum levels which was already present 7 days after the cell transfer. At 6 weeks, mean IgE levels were more than 200-fold above the control values. Host B cells were responsible for the hypersecretion of IgE in stimulatory GVHR since it was also observed when the DBA/2 donor inoculum was depleted of B cells but not when the F1 recipients were irradiated. The induction of IgE secretion required donor CD4+ T cells as treatment of the donor inoculum with lytic anti-CD4 monoclonal antibody (MoAb) completely prevented the occurrence of the hyper IgE whereas depletion of CD8+ cells had no influence on this parameter. The role played by interleukin-4 (IL-4) in this model was analysed in vivo by the administration of the 11B11 anti-IL-4 rat MoAb (total dose 36 mg) during the first 12 days following induction of stimulatory GVHR by 8 x 10(7) DBA/2 spleen cells. This treatment completely prevented the development of hyper IgE whereas the administration of a control rat MoAb had no significant effect. We conclude that stimulatory GVHR in mice is associated with a major increase in serum IgE which is mediated by IL-4.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-2138556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-2459206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-2521244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-2525888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-2582266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-3042039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-3076417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-3260841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-3263424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-3486902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-3491987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-3919312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-6184306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-6195085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-6218218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-6224882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-6338041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-6935293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-6978376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-6978818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-6991585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1671004-7005342
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
133-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1671004-Animals,
pubmed-meshheading:1671004-Antibodies, Monoclonal,
pubmed-meshheading:1671004-Antigens, CD4,
pubmed-meshheading:1671004-B-Lymphocytes,
pubmed-meshheading:1671004-CD4-Positive T-Lymphocytes,
pubmed-meshheading:1671004-Disease Models, Animal,
pubmed-meshheading:1671004-Graft vs Host Disease,
pubmed-meshheading:1671004-Immunoglobulin E,
pubmed-meshheading:1671004-Interleukin-4,
pubmed-meshheading:1671004-Mice,
pubmed-meshheading:1671004-Mice, Inbred C57BL,
pubmed-meshheading:1671004-Mice, Inbred DBA,
pubmed-meshheading:1671004-Spleen
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pubmed:year |
1991
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pubmed:articleTitle |
Hyper IgE in stimulatory graft-versus-host disease: role of interleukin-4.
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pubmed:affiliation |
Department of Nephrology, Hôpital Erasme, Brussels, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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