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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-5-19
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pubmed:abstractText |
Unlike HIV-1-infected people, most HIV-2-infected subjects maintain a healthy CD4+ T cell count and a strong HIV-specific CD4+ T cell response. To define the cellular immunological correlates of good prognosis in HIV-2 infection, we conducted a cross-sectional study of HIV Gag-specific T cell function in HIV-1- and HIV-2-infected Gambians. Using cytokine flow cytometry and lymphoproliferation assays, we show that HIV-specific CD4+ T cells from HIV-2-infected individuals maintained proliferative capacity, were not terminally differentiated (CD57-), and more frequently produced IFN-gamma or IL-2 than CD4+ T cells from HIV-1-infected donors. Polyfunctional (IFN-gamma+/IL-2+) HIV-specific CD4+ T cells were found exclusively in HIV-2+ donors. The disparity in CD4+ T cell responses between asymptomatic HIV-1- and HIV-2-infected subjects was not associated with differences in the proliferative capacity of HIV-specific CD8+ T cells. This study demonstrates that HIV-2-infected donors have a well-preserved and functionally heterogeneous HIV-specific memory CD4+ T cell response that is associated with delayed disease progression in the majority of infected people.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:AlabiAbraham SAS,
pubmed-author:BrenchleyJason MJM,
pubmed-author:DongTaoT,
pubmed-author:DouekDaniel CDC,
pubmed-author:DuvallMelody GMG,
pubmed-author:JayeAssanA,
pubmed-author:JeffriesDavid JDJ,
pubmed-author:KoupRichard ARA,
pubmed-author:McConkeySamuel JSJ,
pubmed-author:McMichaelAndrew JAJ,
pubmed-author:Rowland-JonesSarah LSL,
pubmed-author:TogunToyin OTO,
pubmed-author:WhittleHilton CHC,
pubmed-author:van der SandeMarianneM
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
176
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6973-81
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16709858-Antigens, CD57,
pubmed-meshheading:16709858-CD4 Lymphocyte Count,
pubmed-meshheading:16709858-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16709858-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16709858-Cell Differentiation,
pubmed-meshheading:16709858-Cell Proliferation,
pubmed-meshheading:16709858-Cross-Sectional Studies,
pubmed-meshheading:16709858-Disease Progression,
pubmed-meshheading:16709858-Epitopes, T-Lymphocyte,
pubmed-meshheading:16709858-Gene Products, gag,
pubmed-meshheading:16709858-HIV Infections,
pubmed-meshheading:16709858-HIV Long-Term Survivors,
pubmed-meshheading:16709858-HIV-1,
pubmed-meshheading:16709858-HIV-2,
pubmed-meshheading:16709858-Humans,
pubmed-meshheading:16709858-Interferon-gamma,
pubmed-meshheading:16709858-Interleukin-2,
pubmed-meshheading:16709858-Intracellular Fluid
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pubmed:year |
2006
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pubmed:articleTitle |
Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection.
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pubmed:affiliation |
Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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