| pubmed-article:16709854 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16709854 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:16709854 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:16709854 | lifeskim:mentions | umls-concept:C1333899 | lld:lifeskim |
| pubmed-article:16709854 | lifeskim:mentions | umls-concept:C1325804 | lld:lifeskim |
| pubmed-article:16709854 | lifeskim:mentions | umls-concept:C0019728 | lld:lifeskim |
| pubmed-article:16709854 | lifeskim:mentions | umls-concept:C0282580 | lld:lifeskim |
| pubmed-article:16709854 | lifeskim:mentions | umls-concept:C0376545 | lld:lifeskim |
| pubmed-article:16709854 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:16709854 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16709854 | pubmed:dateCreated | 2006-5-19 | lld:pubmed |
| pubmed-article:16709854 | pubmed:abstractText | The oncofetal Ag immature laminin receptor (OFA-iLR) is a potential target molecule for immunotherapeutic studies in several tumor entities, including hematological malignancies. In the present study, we characterize two HLA-A*0201-presented epitopes eliciting strong OFA-iLR peptide-specific human cytotoxic T cell (CTLs) responses in vitro. Both allogeneic HLA-A*0201-matched and autologous CTLs recognized and killed endogenously OFA-iLR-expressing tumor cell lines and primary malignant cells from patients with hemopoietic malignancies in an MHC-restricted fashion but spared nonmalignant hemopoietic cells. Spontaneous OFA-iLR peptide-specific T cell reactivity was detectable in a significant proportion of leukemia patients. Interestingly, in patients with chronic lymphocytic leukemia and multiple myeloma but not in those with acute myeloid leukemia, significant frequencies of OFA peptide-specific CTLs could be detected in an early stage of disease but disappeared in patients with progressive disease. The identification of OFA-iLR-derived peptide epitopes provides a basis for tumor immunological studies and therapeutic vaccination strategies in patients with OFA-iLR-expressing malignancies. | lld:pubmed |
| pubmed-article:16709854 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16709854 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16709854 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16709854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16709854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16709854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16709854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16709854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16709854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16709854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16709854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16709854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16709854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16709854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16709854 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16709854 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16709854 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16709854 | pubmed:author | pubmed-author:RohrerJamesJ | lld:pubmed |
| pubmed-article:16709854 | pubmed:author | pubmed-author:SchmitzNorber... | lld:pubmed |
| pubmed-article:16709854 | pubmed:author | pubmed-author:KabelitzDiete... | lld:pubmed |
| pubmed-article:16709854 | pubmed:author | pubmed-author:WagnerAndreas... | lld:pubmed |
| pubmed-article:16709854 | pubmed:author | pubmed-author:ZeisMatthiasM | lld:pubmed |
| pubmed-article:16709854 | pubmed:author | pubmed-author:SteinmannJörg... | lld:pubmed |
| pubmed-article:16709854 | pubmed:author | pubmed-author:DregerPeterP | lld:pubmed |
| pubmed-article:16709854 | pubmed:author | pubmed-author:SiegelSandraS | lld:pubmed |
| pubmed-article:16709854 | pubmed:author | pubmed-author:BarsoumAdelA | lld:pubmed |
| pubmed-article:16709854 | pubmed:author | pubmed-author:FriedrichsBir... | lld:pubmed |
| pubmed-article:16709854 | pubmed:author | pubmed-author:WendelerAnnek... | lld:pubmed |
| pubmed-article:16709854 | pubmed:author | pubmed-author:WendelLenaL | lld:pubmed |
| pubmed-article:16709854 | pubmed:author | pubmed-author:CogginJosephJ | lld:pubmed |
| pubmed-article:16709854 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16709854 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16709854 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:16709854 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16709854 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16709854 | pubmed:pagination | 6935-44 | lld:pubmed |
| pubmed-article:16709854 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:meshHeading | pubmed-meshheading:16709854... | lld:pubmed |
| pubmed-article:16709854 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16709854 | pubmed:articleTitle | Identification of HLA-A*0201-presented T cell epitopes derived from the oncofetal antigen-immature laminin receptor protein in patients with hematological malignancies. | lld:pubmed |
| pubmed-article:16709854 | pubmed:affiliation | General Hospital St. Georg, Department of Hematology, Hamburg, Germany. | lld:pubmed |
| pubmed-article:16709854 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:18290 | entrezgene:pubmed | pubmed-article:16709854 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16709854 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16709854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16709854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16709854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16709854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16709854 | lld:pubmed |
