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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-5-19
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pubmed:abstractText |
The oncofetal Ag immature laminin receptor (OFA-iLR) is a potential target molecule for immunotherapeutic studies in several tumor entities, including hematological malignancies. In the present study, we characterize two HLA-A*0201-presented epitopes eliciting strong OFA-iLR peptide-specific human cytotoxic T cell (CTLs) responses in vitro. Both allogeneic HLA-A*0201-matched and autologous CTLs recognized and killed endogenously OFA-iLR-expressing tumor cell lines and primary malignant cells from patients with hemopoietic malignancies in an MHC-restricted fashion but spared nonmalignant hemopoietic cells. Spontaneous OFA-iLR peptide-specific T cell reactivity was detectable in a significant proportion of leukemia patients. Interestingly, in patients with chronic lymphocytic leukemia and multiple myeloma but not in those with acute myeloid leukemia, significant frequencies of OFA peptide-specific CTLs could be detected in an early stage of disease but disappeared in patients with progressive disease. The identification of OFA-iLR-derived peptide epitopes provides a basis for tumor immunological studies and therapeutic vaccination strategies in patients with OFA-iLR-expressing malignancies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A*02:01 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A2 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/RPSA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Laminin,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/immature laminin receptor protein...,
http://linkedlifedata.com/resource/pubmed/chemical/oncofetal antigens
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:BarsoumAdelA,
pubmed-author:CogginJosephJ,
pubmed-author:DregerPeterP,
pubmed-author:FriedrichsBirteB,
pubmed-author:KabelitzDieterD,
pubmed-author:RohrerJamesJ,
pubmed-author:SchmitzNorbertN,
pubmed-author:SiegelSandraS,
pubmed-author:SteinmannJörgJ,
pubmed-author:WagnerAndreasA,
pubmed-author:WendelLenaL,
pubmed-author:WendelerAnnekeA,
pubmed-author:ZeisMatthiasM
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
176
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6935-44
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16709854-Adult,
pubmed-meshheading:16709854-Aged,
pubmed-meshheading:16709854-Antigen Presentation,
pubmed-meshheading:16709854-Antigens, Neoplasm,
pubmed-meshheading:16709854-Cytotoxicity, Immunologic,
pubmed-meshheading:16709854-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:16709854-Dendritic Cells,
pubmed-meshheading:16709854-Epitopes, T-Lymphocyte,
pubmed-meshheading:16709854-Female,
pubmed-meshheading:16709854-HLA-A Antigens,
pubmed-meshheading:16709854-HLA-A2 Antigen,
pubmed-meshheading:16709854-Humans,
pubmed-meshheading:16709854-K562 Cells,
pubmed-meshheading:16709854-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:16709854-Leukemia, Myeloid, Acute,
pubmed-meshheading:16709854-Male,
pubmed-meshheading:16709854-Middle Aged,
pubmed-meshheading:16709854-Multiple Myeloma,
pubmed-meshheading:16709854-Peptide Fragments,
pubmed-meshheading:16709854-Protein Binding,
pubmed-meshheading:16709854-Receptors, Laminin,
pubmed-meshheading:16709854-Ribosomal Proteins,
pubmed-meshheading:16709854-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:16709854-Transfection
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pubmed:year |
2006
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pubmed:articleTitle |
Identification of HLA-A*0201-presented T cell epitopes derived from the oncofetal antigen-immature laminin receptor protein in patients with hematological malignancies.
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pubmed:affiliation |
General Hospital St. Georg, Department of Hematology, Hamburg, Germany.
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pubmed:publicationType |
Journal Article
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