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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-5-19
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pubmed:abstractText |
Adhesion- and degranulation-promoting adapter protein (ADAP) is required in TCR-induced activation and proliferation of peripheral T cells. Loss of ADAP also impairs TCR-initiated inside-out activation of the integrin LFA-1 (CD11a/CD18, alphaLbeta2). In this study, we demonstrate that ADAP-deficient CD4/CD8 double-positive (DP) cells have a diminished ability to proliferate, and that these DP thymocytes up-regulate CD69 poorly in vivo. Moreover, in both MHC class I- and class II-restricted TCR transgenic models, loss of ADAP interferes with both positive and negative selection. ADAP deficiency also impairs the ability of transgene-bearing DP thymocytes to form conjugates with Ag-loaded presenting cells. These findings suggest that ADAP is critical for thymocyte development and selection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
176
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6681-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16709827-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:16709827-Amino Acid Sequence,
pubmed-meshheading:16709827-Animals,
pubmed-meshheading:16709827-Antigen-Presenting Cells,
pubmed-meshheading:16709827-Antigens, CD4,
pubmed-meshheading:16709827-Antigens, CD8,
pubmed-meshheading:16709827-Calcium,
pubmed-meshheading:16709827-Cell Adhesion,
pubmed-meshheading:16709827-Cell Degranulation,
pubmed-meshheading:16709827-Cell Differentiation,
pubmed-meshheading:16709827-Cell Line, Tumor,
pubmed-meshheading:16709827-Cell Proliferation,
pubmed-meshheading:16709827-Female,
pubmed-meshheading:16709827-Lymphocyte Count,
pubmed-meshheading:16709827-Male,
pubmed-meshheading:16709827-Mice,
pubmed-meshheading:16709827-Mice, Knockout,
pubmed-meshheading:16709827-Mice, Transgenic,
pubmed-meshheading:16709827-Molecular Sequence Data,
pubmed-meshheading:16709827-T-Lymphocyte Subsets,
pubmed-meshheading:16709827-Thymus Gland
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pubmed:year |
2006
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pubmed:articleTitle |
Adhesion- and degranulation-promoting adapter protein is required for efficient thymocyte development and selection.
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pubmed:affiliation |
Abramson Family Cancer Research Institute and Department of Laboratory Medicine and Pathology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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