Linked Life Data

16709186

Source:http://linkedlifedata.com/resource/pubmed/id/16709186

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 3
pubmed:dateCreated
2006-5-19
pubmed:abstractText
Mechanical stimuli are important signals in articular cartilage, but what mediates them is unknown. We have shown that extracellular-signal-regulated kinase was activated on cutting and loading articular cartilage, and deduced that this was due to the release of bFGF (basic fibroblast growth factor) from the tissue. bFGF was shown to be extracellular, and by immunohistochemistry, was present in the pericellular matrix of articular chondrocytes attached to the heparan sulphate proteoglycan perlecan. We propose a novel mechanotransduction model, whereby pericellular bFGF, a short distance from the cell surface, becomes available to the cell surface tyrosine kinase receptors when articular cartilage is loaded.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0300-5127
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
456-7
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Basic fibroblast growth factor: an extracellular mechanotransducer in articular cartilage?
pubmed:affiliation
Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, London, UK. t.vincent@imperial.ac.uk
pubmed:publicationType
Journal Article, Review