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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-5-31
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pubmed:abstractText |
Only activated and effector memory T cells are thought to access non-lymphoid tissues. In contrast, naive T cells are thought to circulate only between the blood, lymph and secondary lymphoid organs. We examined the phenotype of endogenous T cells in various non-lymphoid organs and showed that a subset of cells exhibited an apparently naive phenotype and were functionally inactive. FTY720 treatment selectively depleted this population from the non-lymphoid tissues. In addition, RAG-deficient TCR transgenic CD4 and CD8 T cells were present in non-lymphoid tissues in bone marrow chimeric mice and in situ imaging analysis revealed their location in the parenchymal tissues. Moreover, migration of TCR transgenic T cells to non-lymphoid tissues after adoptive transfer was pertussis-toxin resistant. Overall, the results suggest that naive T cells may circulate through non-lymphoid tissues as part of their normal migratory pathway.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD11a,
http://linkedlifedata.com/resource/pubmed/chemical/Ccr7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Propylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR7,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingosine,
http://linkedlifedata.com/resource/pubmed/chemical/fingolimod
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1423-33
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pubmed:dateRevised |
2008-6-5
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pubmed:meshHeading |
pubmed-meshheading:16708400-Animals,
pubmed-meshheading:16708400-Antigens, CD11a,
pubmed-meshheading:16708400-Brain,
pubmed-meshheading:16708400-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16708400-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16708400-Cell Movement,
pubmed-meshheading:16708400-Immunosuppressive Agents,
pubmed-meshheading:16708400-Liver,
pubmed-meshheading:16708400-Lung,
pubmed-meshheading:16708400-Male,
pubmed-meshheading:16708400-Mice,
pubmed-meshheading:16708400-Mice, Inbred C57BL,
pubmed-meshheading:16708400-Mice, Transgenic,
pubmed-meshheading:16708400-Microscopy, Confocal,
pubmed-meshheading:16708400-Pertussis Toxin,
pubmed-meshheading:16708400-Propylene Glycols,
pubmed-meshheading:16708400-Receptors, CCR7,
pubmed-meshheading:16708400-Receptors, Chemokine,
pubmed-meshheading:16708400-Skin,
pubmed-meshheading:16708400-Specific Pathogen-Free Organisms,
pubmed-meshheading:16708400-Sphingosine
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pubmed:year |
2006
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pubmed:articleTitle |
Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway.
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pubmed:affiliation |
Department of Immunology, University of Connecticut Health Center, Farmington, 06030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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