Linked Life Data

16707128

Source:http://linkedlifedata.com/resource/pubmed/id/16707128

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2006-5-24
pubmed:abstractText
Critical changes occurring in Rac-1 molecule, a cytoskeleton organizing small GTPase associated with cell ruffling, have been analyzed in dendritic cells (DCs) derived from monocytes cultured with granulocyte-macrophage colony-stimulating factor and IFN-alpha or IL-4. Although with different kinetics, both agents induced activation of Rac-1 molecule and, more importantly, an upregulation of both protein expression and mRNA transcription. These findings strengthen the role of Rac-1 molecule in the induction of DC differentiation and suggest that, besides its activation, the upregulation of Rac-1 molecule might also play a role in the acquisition of DC mature phenotype.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
580
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3335-9
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Differentiation of monocyte-derived dendritic cells is associated with upregulation and activation of Rac-1 small GTPase.
pubmed:affiliation
Department of Drug Research and Evaluation, Istituto Superiore di Sanita', viale Regina Elena 299, 00161, Rome, Italy.
pubmed:publicationType
Journal Article