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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2006-6-13
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pubmed:abstractText |
Changes in expression profiles for 17 proteins were ascertained in human mature osteoblasts compared to pre-osteoblasts (differentiation markers). A differential approach was used to highlight proteomic changes between human osteosarcoma cells and mature osteoblasts, showing a relative over-expression of 8 proteins (proliferation and tumor indicators), as well as under-expression of proteins also found down-regulated in pre-osteoblasts (specific markers of osteoblast differentiation). Our findings confirmed the differences between cell lines and primary human cell cultures and suggested caution on the use of osteosarcoma to study anti-osteoporotic drugs in humans.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1615-9853
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pubmed:author |
pubmed-author:BernardiniGiuliaG,
pubmed-author:CapperucciCaterinaC,
pubmed-author:ChelliniFrancescaF,
pubmed-author:CollodelGiuliaG,
pubmed-author:D'AmbrosioChiaraC,
pubmed-author:FredianiBrunoB,
pubmed-author:MarcolongoRobertoR,
pubmed-author:MiniRobertaR,
pubmed-author:PaffettiAlessandroA,
pubmed-author:SantucciAnnalisaA,
pubmed-author:ScaloniAndreaA,
pubmed-author:SpreaficoAdrianoA
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3520-32
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16705754-Adult,
pubmed-meshheading:16705754-Alkaline Phosphatase,
pubmed-meshheading:16705754-Bone and Bones,
pubmed-meshheading:16705754-Cell Culture Techniques,
pubmed-meshheading:16705754-Cell Differentiation,
pubmed-meshheading:16705754-Cell Line, Tumor,
pubmed-meshheading:16705754-Cell Proliferation,
pubmed-meshheading:16705754-Cells, Cultured,
pubmed-meshheading:16705754-Core Binding Factor Alpha 1 Subunit,
pubmed-meshheading:16705754-Gene Expression Regulation,
pubmed-meshheading:16705754-Humans,
pubmed-meshheading:16705754-Male,
pubmed-meshheading:16705754-Osteoblasts,
pubmed-meshheading:16705754-Osteocalcin,
pubmed-meshheading:16705754-Osteosarcoma,
pubmed-meshheading:16705754-Proteome,
pubmed-meshheading:16705754-Proteomics,
pubmed-meshheading:16705754-Tumor Markers, Biological
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pubmed:year |
2006
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pubmed:articleTitle |
A proteomic study on human osteoblastic cells proliferation and differentiation.
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pubmed:affiliation |
Dipartimento di Medicina Clinica e Scienze Immunologiche, Policlinico Le Scotte, Università degli Studi di Siena, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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