Source:http://linkedlifedata.com/resource/pubmed/id/16704445
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2006-5-17
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| pubmed:abstractText |
The incidence of infections among patients with thalassaemia and the role of risk factors for infection are uncertain. We studied the occurrence of infections necessitating hospitalisation in 92 homozygous beta-thalassaemia patients who had been followed longitudinally for decades, and investigated the role of potential risk factors for these infections. Pneumonia accounted for 26% of the infections and fever of unknown origin for 14%. Staphylococcus aureus was the major pathogen possibly related to injections associated with intensive chelation with deferoxamine. There was a significant increase in the rate of infection over time, notably after 15 years. Splenectomy correlated with the incidence of infection (P < 0.001) without being confounded by other variables and with highest frequencies of infections present after 10 years. A direct correlation between iron overload and infection was evident only before the initiation of iron-chelating treatment (P < 0.01). Following initiation of deferoxamine, paradoxically, the infection rate increased (P = 0.046). The combination of splenectomy and deferoxamine treatment was associated with the highest adjusted infection rate. Parathyroid dysfunction and glucose-6-phosphate dehydrogenase deficiency were significantly associated with infection (P = 0.02 and P = 0.04 respectively). The infection rate in thalassaemia is affected mainly by the duration of the disease and is increased by splenectomy and, in the long term, by treatment with deferoxamine.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0007-1048
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
133
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
667-74
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16704445-Adolescent,
pubmed-meshheading:16704445-Adult,
pubmed-meshheading:16704445-Bacterial Infections,
pubmed-meshheading:16704445-Child,
pubmed-meshheading:16704445-Deferoxamine,
pubmed-meshheading:16704445-Female,
pubmed-meshheading:16704445-Ferritins,
pubmed-meshheading:16704445-Hospitalization,
pubmed-meshheading:16704445-Humans,
pubmed-meshheading:16704445-Iron Overload,
pubmed-meshheading:16704445-Longitudinal Studies,
pubmed-meshheading:16704445-Male,
pubmed-meshheading:16704445-Opportunistic Infections,
pubmed-meshheading:16704445-Postoperative Period,
pubmed-meshheading:16704445-Risk Factors,
pubmed-meshheading:16704445-Siderophores,
pubmed-meshheading:16704445-Splenectomy,
pubmed-meshheading:16704445-beta-Thalassemia
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Severe infections in thalassaemic patients: prevalence and predisposing factors.
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| pubmed:affiliation |
Department of Clinical Microbiology and Infectious Diseases, Hadassah Medical Centre and School of Medicine, The Hebrew University, Ein-Kerem, Jerusalem, Israel. galia.rahav@sheba.health.gov.il
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| pubmed:publicationType |
Journal Article
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