Source:http://linkedlifedata.com/resource/pubmed/id/16699530
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2006-6-7
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| pubmed:abstractText |
The current study evaluates the role of quantitative measurement of peripheral lymphocyte subsets, especially CD4+ helper T-cell recovery, in predicting transplant outcomes including overall survival (OS) and non-relapse mortality (NRM) after allogeneic stem cell transplantation. A total of 69 allogeneic recipients were included with following diagnoses: acute myeloid leukemia 42, acute lymphoblastic leukemia 5, chronic myeloid leukemia 15, non-Hodgkin's lymphoma 5 and high-risk myelodysplastic syndrome 2. The peripheral lymphocyte subset counts (CD3+ T cells, CD3+4+ helper T cells, CD3+8+ cytotoxic T cells, CD19+ B cells, and CD56+ natural killer cells) were measured at 3, 6 and 12 months. The CD4+ helper T-cell reconstitution at 3 months was strongly correlated with OS (P<0.0001), NRM (P=0.0007), and opportunistic infections (P=0.0108) at the cutoff value of 200 x 10(6)/l CD4(+) helper T cells. Rapid CD4+ helper T-cell recovery was also associated with a higher CD4+ helper T-cell transplant dose (P=0.006) and donor type (P<0.001). An early CD4+ helper T-cell recovery at 3 months correlated with a subsequent faster helper T-cell recovery until 12 months, yet not with B-cell recovery. In a multivariate analysis, rapid recovery of CD4+ helper T cells at 3 months was a favorable prognostic factor together with higher CD34+ cell transplant dose in terms of OS (P=0.001) and NRM (P=0.005).
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
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| pubmed:issn |
0268-3369
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
37
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1119-28
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| pubmed:meshHeading |
pubmed-meshheading:16699530-Adolescent,
pubmed-meshheading:16699530-Adult,
pubmed-meshheading:16699530-Antigens, CD,
pubmed-meshheading:16699530-B-Lymphocytes,
pubmed-meshheading:16699530-Blood Donors,
pubmed-meshheading:16699530-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16699530-Disease-Free Survival,
pubmed-meshheading:16699530-Female,
pubmed-meshheading:16699530-Hematologic Neoplasms,
pubmed-meshheading:16699530-Humans,
pubmed-meshheading:16699530-Lymphocyte Count,
pubmed-meshheading:16699530-Lymphocyte Transfusion,
pubmed-meshheading:16699530-Male,
pubmed-meshheading:16699530-Middle Aged,
pubmed-meshheading:16699530-Opportunistic Infections,
pubmed-meshheading:16699530-Recovery of Function,
pubmed-meshheading:16699530-Stem Cell Transplantation,
pubmed-meshheading:16699530-Time Factors,
pubmed-meshheading:16699530-Transplantation, Homologous,
pubmed-meshheading:16699530-Treatment Outcome
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Rapid helper T-cell recovery above 200 x 10 6/l at 3 months correlates to successful transplant outcomes after allogeneic stem cell transplantation.
|
| pubmed:affiliation |
Department of Hematology/Oncology, Kyungpook National University Hospital, 50 Samduk 2-ga, Jung-Gu, Daegu 700-721, Korea.
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| pubmed:publicationType |
Journal Article
|