Linked Life Data

16698213

Source:http://linkedlifedata.com/resource/pubmed/id/16698213

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-5-30
pubmed:abstractText
The aim of this study was to develop a rapid and sensitive method for in vivo and real time monitoring unbound ornidazole (ONZ) and tinidazole (TNZ) in rabbit blood using capillary electrophoresis coupled with microdialysis. The UV wavelength was set at 214 nm and all separations were performed in 20 mM Tris-H3PO4 (pH 1.5) buffer. Microdialysis probes were perfused at 4 microl/min resulting in relative recoveries of 33.1+/-3.6% and 34.8+/-3.3% (n=3) for ONZ and TNZ, respectively. The linearity was studied in the concentration range of 1.0-412 microg/ml for ONZ and 1.0-520 microg/ml for TNZ. The detection limits were 0.7 microg/ml for ONZ and 0.6 microg/ml for TNZ (S/N=3). All separation could be achieved within 15 min. This method has been successfully applied to the pharmacokinetic study of ONZ and TNZ in rabbit blood.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0731-7085
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1453-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
In vivo and real time determination of ornidazole and tinidazole and pharmacokinetic study by capillary electrophoresis with microdialysis.
pubmed:affiliation
Department of Chemistry, Shaanxi Normal University, Xi'an 710062, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't