Linked Life Data

16697967

Source:http://linkedlifedata.com/resource/pubmed/id/16697967

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-5-15
pubmed:abstractText
Aging in humans is associated with progressive decline in T cell function, hyperimmunoglobulinemia, increased prevalence of autoantibodies and decline in naïve CD8(+) T cells and accumulation of memory T cells, which appears to be oligoclonal and display feature of senescence, that is, decreased replication, short telomere length and resistance to apoptosis. Recently memory T cells have been further subdivided into central and effector memory T cells, based upon their migratory and homing properties. They are identified by a number of cell surface makers. In this brief review we will discuss molecular mechanisms of apoptosis in naïve and various types of memory T cells to possibly explain the changes observed in aging, which are very similar to certain autoimmune diseases.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1568-9972
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
264-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Molecular mechanisms of TNF-alpha-induced apoptosis in naïve and memory T cell subsets.
pubmed:affiliation
Division of Basic and Clinical Immunology, University of California, Irvine, 92697, USA. sgupta@ici.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural