Linked Life Data

16697370

Source:http://linkedlifedata.com/resource/pubmed/id/16697370

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pubmed-article:16697370pubmed:abstractTextThis study examines cell death and proliferation in the white matter after neonatal stroke. In postnatal day 7 injured rat, there was a marked reduction in myelin basic protein (MBP) immunostaining mainly corresponding to numerous pyknotic immature oligodendrocytes and TUNEL-positive astrocytes in the ipsilateral external capsule. In contrast, a substantial restoration of MBP, as indicated by the MBP ratio of left-to-right, occurred in the cingulum at 48 (1.27 +/- 0.12) and 72 (1.30 +/- 0.18, P < 0.05) h of recovery as compared to age-matched controls (1.03 +/- 0.14). Ki-67 immunostaining revealed a first peak of newly generated cells in the dorsolateral hippocampal subventricular zone and cingulum at 72 h after reperfusion. Double immunofluorescence revealed that most of the Ki-67-positive cells were astrocytes at 48 h and NG2 pre-oligodendrocytes at 72 h of recovery. Microglia infiltration occurs over several days in the cingulum, and a huge quantity of macrophages reached the subcortical white matter where they engulfed immature oligodendrocytes. The overall results suggest that the persistent activation of microglia involves a chronic component of immunoinflammation, which overwhelms repair processes and contributes to cystic growth in the developing brain.lld:pubmed
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pubmed-article:16697370pubmed:articleTitleGlial activation in white matter following ischemia in the neonatal P7 rat brain.lld:pubmed
pubmed-article:16697370pubmed:affiliationUMR-CNRS 7102, Université Pierre et Marie Curie, HICD, case 14, 9 quai St-Bernard, 75005 Paris, France; Service de Néonatologie, Hôpital Armand Trousseau, 75012 Paris, France.lld:pubmed
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