Source:http://linkedlifedata.com/resource/pubmed/id/16697370
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2006-6-26
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| pubmed:abstractText |
This study examines cell death and proliferation in the white matter after neonatal stroke. In postnatal day 7 injured rat, there was a marked reduction in myelin basic protein (MBP) immunostaining mainly corresponding to numerous pyknotic immature oligodendrocytes and TUNEL-positive astrocytes in the ipsilateral external capsule. In contrast, a substantial restoration of MBP, as indicated by the MBP ratio of left-to-right, occurred in the cingulum at 48 (1.27 +/- 0.12) and 72 (1.30 +/- 0.18, P < 0.05) h of recovery as compared to age-matched controls (1.03 +/- 0.14). Ki-67 immunostaining revealed a first peak of newly generated cells in the dorsolateral hippocampal subventricular zone and cingulum at 72 h after reperfusion. Double immunofluorescence revealed that most of the Ki-67-positive cells were astrocytes at 48 h and NG2 pre-oligodendrocytes at 72 h of recovery. Microglia infiltration occurs over several days in the cingulum, and a huge quantity of macrophages reached the subcortical white matter where they engulfed immature oligodendrocytes. The overall results suggest that the persistent activation of microglia involves a chronic component of immunoinflammation, which overwhelms repair processes and contributes to cystic growth in the developing brain.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Fibrillary Acidic Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Ki-67 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Basic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/chondroitin sulfate proteoglycan 4
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0014-4886
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
199
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
103-12
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16697370-Animals,
pubmed-meshheading:16697370-Animals, Newborn,
pubmed-meshheading:16697370-Antigens,
pubmed-meshheading:16697370-Brain,
pubmed-meshheading:16697370-Brain Infarction,
pubmed-meshheading:16697370-Cell Count,
pubmed-meshheading:16697370-Female,
pubmed-meshheading:16697370-Fluorescent Antibody Technique,
pubmed-meshheading:16697370-Functional Laterality,
pubmed-meshheading:16697370-Glial Fibrillary Acidic Protein,
pubmed-meshheading:16697370-In Situ Nick-End Labeling,
pubmed-meshheading:16697370-Ischemia,
pubmed-meshheading:16697370-Ki-67 Antigen,
pubmed-meshheading:16697370-Male,
pubmed-meshheading:16697370-Myelin Basic Proteins,
pubmed-meshheading:16697370-Neuroglia,
pubmed-meshheading:16697370-Proteoglycans,
pubmed-meshheading:16697370-Rats,
pubmed-meshheading:16697370-Statistics, Nonparametric,
pubmed-meshheading:16697370-Time Factors
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| pubmed:year |
2006
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| pubmed:articleTitle |
Glial activation in white matter following ischemia in the neonatal P7 rat brain.
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| pubmed:affiliation |
UMR-CNRS 7102, Université Pierre et Marie Curie, HICD, case 14, 9 quai St-Bernard, 75005 Paris, France; Service de Néonatologie, Hôpital Armand Trousseau, 75012 Paris, France.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|