rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1-2
|
pubmed:dateCreated |
2006-6-5
|
pubmed:abstractText |
Somatostatin released from capsaicin-sensitive afferents exerts systemic anti-nociceptive actions, presumably via somatostatin receptor subtype 4 (sst4). In the present study, the antinociceptive effects of a novel somatostatin sst4 receptor selective peptidomimetic compound, J-2156 (1-100 microg/kg i.p.), were examined. J-2156 inhibited nocifensive behaviour of mice in the second phase of the formalin test. Adjuvant-evoked chronic inflammatory mechanical allodynia was decreased in rats treated with J-2156 for 21 days. Sciatic nerve ligation-induced neuropathic mechanical hyperalgesia was inhibited by J-2156 on the seventh postoperative day. Results obtained using this highly selective agonist suggest that somatostatin sst4 receptors represent a promising target for new perspectives in analgesic therapy.
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pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0014-2999
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
6
|
pubmed:volume |
539
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
71-5
|
pubmed:dateRevised |
2007-8-13
|
pubmed:meshHeading |
pubmed-meshheading:16697366-Acute Disease,
pubmed-meshheading:16697366-Analgesics,
pubmed-meshheading:16697366-Animals,
pubmed-meshheading:16697366-Butanes,
pubmed-meshheading:16697366-Chronic Disease,
pubmed-meshheading:16697366-Hyperalgesia,
pubmed-meshheading:16697366-Male,
pubmed-meshheading:16697366-Membrane Proteins,
pubmed-meshheading:16697366-Mice,
pubmed-meshheading:16697366-Mice, Inbred BALB C,
pubmed-meshheading:16697366-Naphthalenes,
pubmed-meshheading:16697366-Pain,
pubmed-meshheading:16697366-Pain Measurement,
pubmed-meshheading:16697366-Pain Threshold,
pubmed-meshheading:16697366-Physical Stimulation,
pubmed-meshheading:16697366-Rats,
pubmed-meshheading:16697366-Rats, Wistar,
pubmed-meshheading:16697366-Receptors, Somatostatin,
pubmed-meshheading:16697366-Sulfones,
pubmed-meshheading:16697366-Touch
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pubmed:year |
2006
|
pubmed:articleTitle |
Analgesic effects of the somatostatin sst4 receptor selective agonist J-2156 in acute and chronic pain models.
|
pubmed:affiliation |
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, Pécs-7624 Szigeti str. 12, Hungary.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|