Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2006-6-5
pubmed:abstractText
Somatostatin released from capsaicin-sensitive afferents exerts systemic anti-nociceptive actions, presumably via somatostatin receptor subtype 4 (sst4). In the present study, the antinociceptive effects of a novel somatostatin sst4 receptor selective peptidomimetic compound, J-2156 (1-100 microg/kg i.p.), were examined. J-2156 inhibited nocifensive behaviour of mice in the second phase of the formalin test. Adjuvant-evoked chronic inflammatory mechanical allodynia was decreased in rats treated with J-2156 for 21 days. Sciatic nerve ligation-induced neuropathic mechanical hyperalgesia was inhibited by J-2156 on the seventh postoperative day. Results obtained using this highly selective agonist suggest that somatostatin sst4 receptors represent a promising target for new perspectives in analgesic therapy.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
539
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-5
pubmed:dateRevised
2007-8-13
pubmed:meshHeading
pubmed-meshheading:16697366-Acute Disease, pubmed-meshheading:16697366-Analgesics, pubmed-meshheading:16697366-Animals, pubmed-meshheading:16697366-Butanes, pubmed-meshheading:16697366-Chronic Disease, pubmed-meshheading:16697366-Hyperalgesia, pubmed-meshheading:16697366-Male, pubmed-meshheading:16697366-Membrane Proteins, pubmed-meshheading:16697366-Mice, pubmed-meshheading:16697366-Mice, Inbred BALB C, pubmed-meshheading:16697366-Naphthalenes, pubmed-meshheading:16697366-Pain, pubmed-meshheading:16697366-Pain Measurement, pubmed-meshheading:16697366-Pain Threshold, pubmed-meshheading:16697366-Physical Stimulation, pubmed-meshheading:16697366-Rats, pubmed-meshheading:16697366-Rats, Wistar, pubmed-meshheading:16697366-Receptors, Somatostatin, pubmed-meshheading:16697366-Sulfones, pubmed-meshheading:16697366-Touch
pubmed:year
2006
pubmed:articleTitle
Analgesic effects of the somatostatin sst4 receptor selective agonist J-2156 in acute and chronic pain models.
pubmed:affiliation
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, Pécs-7624 Szigeti str. 12, Hungary.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't