| pubmed-article:16696294 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16696294 | lifeskim:mentions | umls-concept:C0949888 | lld:lifeskim |
| pubmed-article:16696294 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:16696294 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16696294 | lifeskim:mentions | umls-concept:C0149566 | lld:lifeskim |
| pubmed-article:16696294 | lifeskim:mentions | umls-concept:C0022116 | lld:lifeskim |
| pubmed-article:16696294 | lifeskim:mentions | umls-concept:C0815279 | lld:lifeskim |
| pubmed-article:16696294 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16696294 | pubmed:dateCreated | 2006-5-15 | lld:pubmed |
| pubmed-article:16696294 | pubmed:abstractText | The neuroprotective potential of ethanol:water (1:1) extract of rhizomes of Acorus calamus (AC-002) has been investigated in middle cerebral artery occlusion (MCAO)-induced ischaemia in rats. A significant behavioural impairment in Rota-Rod performance and grid walking was observed in rats, 72 hours after MCAO as compared to sham-operated animals. These rats also exhibited an increase in lipid peroxidation (cortex -157%, corpus striatum - 58%) and a decrease in glutathione levels (cortex - 59%, corpus striatum - 34%) and superoxide dismutase (SOD) activity (cortex - 64%, corpus striatum - 32%) as compared to sham-operated animals. Ischaemic rats treated with AC-002 (25 mg/kg, p.o.) exhibited a significant improvement in neurobehavioural performance viz. Rota-Rod performance and grid walking as compared to the MCAO group. Interestingly, treatment with AC-002 in MCAO rats significantly decreased malonaldialdehyde levels in cortex as compared to ischaemic rats. A significant increase in reduced glutathione levels and SOD activity was also observed both in cortex and corpus striatum in MCAO rats treated with AC-002 in comparison to MCAO rats. Treatment with AC-002 in MCAO rats also reduced the contralateral cortical infarct area (19%) as compared to MCAO rats (33%). Neurological function score was improved in the AC-002-treated rats as compared to the MCAO group. The results of the present study indicate the neuroprotective efficacy of A. calamus in the rat model of ischaemia. | lld:pubmed |
| pubmed-article:16696294 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16696294 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16696294 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16696294 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16696294 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16696294 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16696294 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16696294 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16696294 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16696294 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16696294 | pubmed:issn | 0960-3271 | lld:pubmed |
| pubmed-article:16696294 | pubmed:author | pubmed-author:KhanM YMY | lld:pubmed |
| pubmed-article:16696294 | pubmed:author | pubmed-author:ShuklaPradeep... | lld:pubmed |
| pubmed-article:16696294 | pubmed:author | pubmed-author:KhannaVinay... | lld:pubmed |
| pubmed-article:16696294 | pubmed:author | pubmed-author:MauryaRakeshR | lld:pubmed |
| pubmed-article:16696294 | pubmed:author | pubmed-author:SrimalRikhab... | lld:pubmed |
| pubmed-article:16696294 | pubmed:author | pubmed-author:AliM MohdMM | lld:pubmed |
| pubmed-article:16696294 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16696294 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:16696294 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16696294 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16696294 | pubmed:pagination | 187-94 | lld:pubmed |
| pubmed-article:16696294 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16696294 | pubmed:meshHeading | pubmed-meshheading:16696294... | lld:pubmed |
| pubmed-article:16696294 | pubmed:meshHeading | pubmed-meshheading:16696294... | lld:pubmed |
| pubmed-article:16696294 | pubmed:meshHeading | pubmed-meshheading:16696294... | lld:pubmed |
| pubmed-article:16696294 | pubmed:meshHeading | pubmed-meshheading:16696294... | lld:pubmed |
| pubmed-article:16696294 | pubmed:meshHeading | pubmed-meshheading:16696294... | lld:pubmed |
| pubmed-article:16696294 | pubmed:meshHeading | pubmed-meshheading:16696294... | lld:pubmed |
| pubmed-article:16696294 | pubmed:meshHeading | pubmed-meshheading:16696294... | lld:pubmed |
| pubmed-article:16696294 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16696294 | pubmed:articleTitle | Neuroprotective effect of Acorus calamus against middle cerebral artery occlusion-induced ischaemia in rat. | lld:pubmed |
| pubmed-article:16696294 | pubmed:affiliation | Industrial Toxicology Research Centre, PO Box 80, M.G. Marg, Lucknow 226001, India. | lld:pubmed |
| pubmed-article:16696294 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16696294 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16696294 | lld:pubmed |
