Source:http://linkedlifedata.com/resource/pubmed/id/16696294
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2006-5-15
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| pubmed:abstractText |
The neuroprotective potential of ethanol:water (1:1) extract of rhizomes of Acorus calamus (AC-002) has been investigated in middle cerebral artery occlusion (MCAO)-induced ischaemia in rats. A significant behavioural impairment in Rota-Rod performance and grid walking was observed in rats, 72 hours after MCAO as compared to sham-operated animals. These rats also exhibited an increase in lipid peroxidation (cortex -157%, corpus striatum - 58%) and a decrease in glutathione levels (cortex - 59%, corpus striatum - 34%) and superoxide dismutase (SOD) activity (cortex - 64%, corpus striatum - 32%) as compared to sham-operated animals. Ischaemic rats treated with AC-002 (25 mg/kg, p.o.) exhibited a significant improvement in neurobehavioural performance viz. Rota-Rod performance and grid walking as compared to the MCAO group. Interestingly, treatment with AC-002 in MCAO rats significantly decreased malonaldialdehyde levels in cortex as compared to ischaemic rats. A significant increase in reduced glutathione levels and SOD activity was also observed both in cortex and corpus striatum in MCAO rats treated with AC-002 in comparison to MCAO rats. Treatment with AC-002 in MCAO rats also reduced the contralateral cortical infarct area (19%) as compared to MCAO rats (33%). Neurological function score was improved in the AC-002-treated rats as compared to the MCAO group. The results of the present study indicate the neuroprotective efficacy of A. calamus in the rat model of ischaemia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
0960-3271
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
187-94
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:16696294-Acorus,
pubmed-meshheading:16696294-Animals,
pubmed-meshheading:16696294-Body Weight,
pubmed-meshheading:16696294-Brain Ischemia,
pubmed-meshheading:16696294-Glutathione,
pubmed-meshheading:16696294-Lipid Peroxidation,
pubmed-meshheading:16696294-Male,
pubmed-meshheading:16696294-Middle Cerebral Artery,
pubmed-meshheading:16696294-Nerve Tissue Proteins,
pubmed-meshheading:16696294-Neuroprotective Agents,
pubmed-meshheading:16696294-Oxidation-Reduction,
pubmed-meshheading:16696294-Plant Extracts,
pubmed-meshheading:16696294-Plant Roots,
pubmed-meshheading:16696294-Postural Balance,
pubmed-meshheading:16696294-Psychomotor Performance,
pubmed-meshheading:16696294-Rats,
pubmed-meshheading:16696294-Rats, Wistar,
pubmed-meshheading:16696294-Superoxide Dismutase
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Neuroprotective effect of Acorus calamus against middle cerebral artery occlusion-induced ischaemia in rat.
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| pubmed:affiliation |
Industrial Toxicology Research Centre, PO Box 80, M.G. Marg, Lucknow 226001, India.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|