| pubmed-article:16696017 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16696017 | lifeskim:mentions | umls-concept:C0007137 | lld:lifeskim |
| pubmed-article:16696017 | lifeskim:mentions | umls-concept:C0460004 | lld:lifeskim |
| pubmed-article:16696017 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:16696017 | lifeskim:mentions | umls-concept:C1413172 | lld:lifeskim |
| pubmed-article:16696017 | lifeskim:mentions | umls-concept:C0525036 | lld:lifeskim |
| pubmed-article:16696017 | lifeskim:mentions | umls-concept:C1521871 | lld:lifeskim |
| pubmed-article:16696017 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16696017 | pubmed:dateCreated | 2010-6-28 | lld:pubmed |
| pubmed-article:16696017 | pubmed:abstractText | Aims-To determine cyclin D1 gene amplification and expression levels in head and neck squamous cell carcinoma (HNSCC) patients.Methods-Total RNA and genomic DNA were isolated from 40 samples of HNSCC tissue and matched normal tissue and were hybridised with a cyclin D1 cDNA probe. Northern and Southern analyses were used to detect mRNA overexpression and cyclin D1 gene amplification, respectively.Results-15 of the 40 HNSCC samples examined (38%) showed cyclin D1 gene amplification. Of these 15 samples, all 13 from which RNA was available showed increased cyclin D1 expression.Conclusions-HNSCC patients with both amplification and overexpression of the cyclin D1 gene are at greater risk than patients who showed no cyclin D1 gene amplification; amplification and over-expression of the cyclin D1 gene may play an important role in the progression of HNSCC and in clinical outcome. | lld:pubmed |
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| pubmed-article:16696017 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16696017 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16696017 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:16696017 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16696017 | pubmed:issn | 1355-2910 | lld:pubmed |
| pubmed-article:16696017 | pubmed:author | pubmed-author:WangLL | lld:pubmed |
| pubmed-article:16696017 | pubmed:author | pubmed-author:StambrookP... | lld:pubmed |
| pubmed-article:16696017 | pubmed:author | pubmed-author:PavelicZ PZP | lld:pubmed |
| pubmed-article:16696017 | pubmed:author | pubmed-author:RadackKK | lld:pubmed |
| pubmed-article:16696017 | pubmed:author | pubmed-author:GluckmanJ LJL | lld:pubmed |
| pubmed-article:16696017 | pubmed:author | pubmed-author:LiY QYQ | lld:pubmed |
| pubmed-article:16696017 | pubmed:author | pubmed-author:WangXX | lld:pubmed |
| pubmed-article:16696017 | pubmed:author | pubmed-author:GleichLL | lld:pubmed |
| pubmed-article:16696017 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16696017 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:16696017 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16696017 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16696017 | pubmed:pagination | M256-9 | lld:pubmed |
| pubmed-article:16696017 | pubmed:dateRevised | 2010-9-15 | lld:pubmed |
| pubmed-article:16696017 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:16696017 | pubmed:articleTitle | Amplification and overexpression of the cyclin D1 gene in head and neck squamous cell carcinoma. | lld:pubmed |
| pubmed-article:16696017 | pubmed:affiliation | Department of Cell Biology, Neurobiology and Anatomy, College of Medicine, University of Cincinnati, 231 Bethesda Avenue, Cincinnati, Ohio 45267-0521, USA. | lld:pubmed |
| pubmed-article:16696017 | pubmed:publicationType | Journal Article | lld:pubmed |
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