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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1994-2-22
|
| pubmed:abstractText |
Minor labial salivary glands obtained at biopsy from patients with Sjögren's syndrome were investigated by immunomorphological methods for the presence of monocyte-derived macrophages. According to our observations published earlier the immunomorphological detection of factor XIII subunit a is a useful marker for recognizing cells of monocyte/macrophage lineage. Factor XIII subunit a was detected by a highly sensitive immunoperoxidase staining, and cells containing this coagulation enzyme were characterized by double immunofluorescence stainings. Factor XIII subunit a+ cells were found to be highly accumulated at the interface of normal tissue and peritubular infiltrate. In double immunofluorescence labelling systems factor XIII subunit a+ cells were simultaneously labelled by RFD7 and Dako-antimacrophage monoclonal antibodies. They also expressed HLA-DR antigen as revealed by a reaction with RFDR2 monoclonal antibody. The results suggest that monocyte-derived tissue macrophages are present in salivary glands of patients with Sjögren's syndrome and have a characteristic distribution. It can be assumed that they have a role in the demarcation of peritubular inflammation and thus have an effect on the progression of the disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1018-9068
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
261-5
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1669586-Adult,
pubmed-meshheading:1669586-Aged,
pubmed-meshheading:1669586-Factor XIII,
pubmed-meshheading:1669586-Female,
pubmed-meshheading:1669586-Fluorescent Antibody Technique,
pubmed-meshheading:1669586-HLA-DR Antigens,
pubmed-meshheading:1669586-Humans,
pubmed-meshheading:1669586-Immunoenzyme Techniques,
pubmed-meshheading:1669586-Macrophages,
pubmed-meshheading:1669586-Middle Aged,
pubmed-meshheading:1669586-Salivary Glands,
pubmed-meshheading:1669586-Sjogren's Syndrome
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Macrophage containing factor XIII subunit a in salivary glands of patients with Sjögren's syndrome.
|
| pubmed:affiliation |
3rd Department of Medicine, University Medical School, Debrecen, Hungary.
|
| pubmed:publicationType |
Journal Article
|