Linked Life Data

1669174

Source:http://linkedlifedata.com/resource/pubmed/id/1669174

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
43-44
pubmed:dateCreated
1993-11-18
pubmed:abstractText
Pharmacokinetic parameters of thiamazole in hyperthyroid patients (40 subjects with Graves-Basedow disease--32 female and 8 male patients) and in healthy individuals (8 subjects--5 women and 3 men) were compared. A one-compartment model was used for the analysis of examined pharmacokinetic parameters. Area under thiamazole concentration curve (AUC) and thiamazole peak plasma concentration (cmax) were significantly decreased in hyperthyroid patients in comparison with healthy individuals. An analysis of other pharmacokinetic parameters suggests that observed differences seem to depend upon lowered and retarded thiamazole absorption from the gut and acceleration of drug metabolism in hepatic microsomal system in hyperthyroid patients.
pubmed:language
pol
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0032-3756
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
838-40
pubmed:dateRevised
2008-6-20
pubmed:meshHeading
pubmed:articleTitle
[Comparison of thiamazole pharmacokinetics in healthy individuals and patients with hyperthyroidism].
pubmed:affiliation
Kliniki Endokrynologii i Chorób Przemiany Materii PAM w Szczecinie.
pubmed:publicationType
Journal Article, Comparative Study, English Abstract