| pubmed-article:16691488 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16691488 | lifeskim:mentions | umls-concept:C0242643 | lld:lifeskim |
| pubmed-article:16691488 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:16691488 | lifeskim:mentions | umls-concept:C0596902 | lld:lifeskim |
| pubmed-article:16691488 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:16691488 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16691488 | pubmed:dateCreated | 2006-5-12 | lld:pubmed |
| pubmed-article:16691488 | pubmed:abstractText | Human P-glycoprotein (ABCB1) is a primary multidrug transporter located in plasma membranes, that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. P-glycoprotein employs a most unusual molecular mechanism to perform this drug transport function. Here we review our work to elucidate the molecular mechanism of drug transport by P-glycoprotein. High level heterologous expression of human P-glycoprotein, in the yeast Saccharomyces cerevisiae, has facilitated biophysical studies in purified proteoliposome preparations. Development of novel spin-labeled transport substrates has allowed for quantitative and rigorous measurements of drug transport in real time by EPR spectroscopy. We have developed a new drug transport model of P-glycoprotein from the results of mutagenic, quantitative thermodynamic and kinetic studies. This model satisfactorily accounts for most of the unusual kinetic, coupling, and physiological features of P-glycoprotein. Additionally, an atomic detail structural model of P-glycoprotein has been devised to place our results within a proper structural context. | lld:pubmed |
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| pubmed-article:16691488 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16691488 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16691488 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16691488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16691488 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16691488 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16691488 | pubmed:issn | 0145-479X | lld:pubmed |
| pubmed-article:16691488 | pubmed:author | pubmed-author:OmoteHiroshiH | lld:pubmed |
| pubmed-article:16691488 | pubmed:author | pubmed-author:Al-ShawiMarwa... | lld:pubmed |
| pubmed-article:16691488 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16691488 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:16691488 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16691488 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16691488 | pubmed:pagination | 489-96 | lld:pubmed |
| pubmed-article:16691488 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16691488 | pubmed:meshHeading | pubmed-meshheading:16691488... | lld:pubmed |
| pubmed-article:16691488 | pubmed:meshHeading | pubmed-meshheading:16691488... | lld:pubmed |
| pubmed-article:16691488 | pubmed:meshHeading | pubmed-meshheading:16691488... | lld:pubmed |
| pubmed-article:16691488 | pubmed:meshHeading | pubmed-meshheading:16691488... | lld:pubmed |
| pubmed-article:16691488 | pubmed:meshHeading | pubmed-meshheading:16691488... | lld:pubmed |
| pubmed-article:16691488 | pubmed:meshHeading | pubmed-meshheading:16691488... | lld:pubmed |
| pubmed-article:16691488 | pubmed:meshHeading | pubmed-meshheading:16691488... | lld:pubmed |
| pubmed-article:16691488 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16691488 | pubmed:articleTitle | The remarkable transport mechanism of P-glycoprotein: a multidrug transporter. | lld:pubmed |
| pubmed-article:16691488 | pubmed:affiliation | Department of Molecular Physiology and Biological Physics, University of Virginia Health System, P.O. Box 800736, Charlottesville, Virginia, 22908-0736, USA. | lld:pubmed |
| pubmed-article:16691488 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16691488 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:16691488 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:5243 | entrezgene:pubmed | pubmed-article:16691488 | lld:entrezgene |
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