Source:http://linkedlifedata.com/resource/pubmed/id/16691430
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2006-5-12
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pubmed:abstractText |
Vitiligo is an acquired depigmentary disorder of the skin, characterized by incomplete penetrance, multiple susceptibility loci and genetic heterogeneity. An immunologic hypothesis is currently advanced as a possible pathogenesis of vitiligo. The cytokines have an important role in pathogenesis of autoimmunity in which tumor necrosis factor-alpha (TNF-alpha), a paracrine inhibitor of melanocytes, is especially important. Several single-nucleotide polymorphisms (SNP) have been identified in the human TNF gene promoter. The polymorphism at position -308 (TNF-308), which involves substituting G for A and designing the AA genotype, leads to a higher rate of TNF gene transcription than the wild-type GG genotype in in vitro expression studies. It has also been linked to increased susceptibility to several chronic metabolic, degenerative, inflammatory and autoimmune diseases. Therefore, we investigated the TNF-alpha-308 SNP in patients with vitiligo. We examined 61 patients with vitiligo. Healthy age-, ethnically- and sex-matched individuals (n = 123) served as controls. Polymerase chain reaction amplification was used for analysis of the polymorphism at position -308 in promoter of TNF-alpha gene. We found that the distribution of TNF-alpha genotypes in vitiligo patients did not differ from that in control subjects (P > 0.05). Moreover, there was no association between TNF-alpha genotypes and types of vitiligo. In conclusion, we suggest that TNF-alpha-308 SNP is not a genetic risk factor for vitiligo susceptibility.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0340-3696
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
298
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
46-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16691430-Case-Control Studies,
pubmed-meshheading:16691430-Female,
pubmed-meshheading:16691430-Genetic Predisposition to Disease,
pubmed-meshheading:16691430-Genotype,
pubmed-meshheading:16691430-Humans,
pubmed-meshheading:16691430-Male,
pubmed-meshheading:16691430-Polymorphism, Single Nucleotide,
pubmed-meshheading:16691430-Promoter Regions, Genetic,
pubmed-meshheading:16691430-Risk Factors,
pubmed-meshheading:16691430-Tumor Necrosis Factor-alpha,
pubmed-meshheading:16691430-Vitiligo
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pubmed:year |
2006
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pubmed:articleTitle |
Lack of association with TNF-alpha-308 promoter polymorphism in patients with vitiligo.
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pubmed:affiliation |
Department of Dermatology, School of Medicine, Mersin University, 33079 Mersin, Turkey. aycacordan@yahoo.com
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pubmed:publicationType |
Journal Article
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