Source:http://linkedlifedata.com/resource/pubmed/id/16690228
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2007-2-13
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| pubmed:abstractText |
A cytological, immunophenotypical and cytogenetical study of 136 chronic B-cell proliferations (93 CLL, 43 B-cell lymphomas) was led in order to precise diagnosis and to characterize and appreciate chromosomal rearrangements. In this series, mainly selected on blood lymphocytosis criteria, B-CLL were twice more frequent than small B-cell lymphomas. Probes used revealed cryptic abnormalities, which remained unknown by conventional cytogenetics (CC). The frequency of clonal abnormalities (CC and FISH) was 74.8% for this series, with 74.4% for lymphomas and 75.3% for CLL, mainly of Binet stage A (69 A, 13 B, 1 C, 10 unspecified). Proportion was 88.4% in A stages and 84.6% in B stages. In CLL, 13q14 cryptic deletions and translocations were widely majority, 14q32 translocations and trisomy 12 being predominant in lymphoma series. Interphase FISH study of non-clonal metaphasic abnormalities with locus-specific probes often revealed unrecognised clones.
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| pubmed:language |
fre
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
|
| pubmed:issn |
0369-8114
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| pubmed:author |
pubmed-author:AudhuyBB,
pubmed-author:BergeratJ-PJP,
pubmed-author:FalkenrodtAA,
pubmed-author:FohrerCC,
pubmed-author:GaloisyA-CAC,
pubmed-author:GervaisCC,
pubmed-author:HeliasCC,
pubmed-author:HerbrechtRR,
pubmed-author:LessardMM,
pubmed-author:LeymarieVV,
pubmed-author:LioureBB,
pubmed-author:MauvieuxLL,
pubmed-author:MazurierII,
pubmed-author:MoskovtchenkoPP,
pubmed-author:StruskiSS
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| pubmed:issnType |
Print
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| pubmed:volume |
55
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
59-72
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16690228-Aneuploidy,
pubmed-meshheading:16690228-Chromosome Aberrations,
pubmed-meshheading:16690228-Chromosomes, Human,
pubmed-meshheading:16690228-Chromosomes, Human, Pair 13,
pubmed-meshheading:16690228-Clone Cells,
pubmed-meshheading:16690228-Cohort Studies,
pubmed-meshheading:16690228-Female,
pubmed-meshheading:16690228-Humans,
pubmed-meshheading:16690228-Immunophenotyping,
pubmed-meshheading:16690228-In Situ Hybridization, Fluorescence,
pubmed-meshheading:16690228-Karyotyping,
pubmed-meshheading:16690228-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:16690228-Lymphoma, B-Cell,
pubmed-meshheading:16690228-Lymphoproliferative Disorders,
pubmed-meshheading:16690228-Male,
pubmed-meshheading:16690228-Neoplasm Staging,
pubmed-meshheading:16690228-Sequence Deletion
|
| pubmed:year |
2007
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| pubmed:articleTitle |
[A cytological, immunophenotypical and cytogenetical study of 136 consecutive cases of B-cell chronic lymphoid hemopathies].
|
| pubmed:affiliation |
Laboratoire d'Hématologie, Service d'Hématologie Biologique, Pôle d'Oncohématologie, Hôpital de Hautepierre, avenue Molière, 67092 Strasbourg cedex, France.
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| pubmed:publicationType |
Journal Article,
English Abstract
|