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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-4
|
| pubmed:dateCreated |
1993-5-25
|
| pubmed:abstractText |
Patch-clamp technique was used in order to study properties of the steady-state Na-channel in snail neurons. Experiments revealed that Pb-ions, applied extracellularly, close these channels, which are preferably in open state at the resting membrane potential. Elementary currents have a linear current-voltage (I-V) relationship with single channel conductance of 14 pS between -100 and -40 mV both in control saline and in the presence of 50 microM Pb in the pipette. Pb-ions decreased the mean open and increased the mean closed time. It was found that both open and closed times showed little voltage-dependence, however the probabilities of the open and closed times proved to be voltage-dependent. Open and closed time histograms were fitted by one exponential, therefore first order kinetics were assumed for the blocking effect of Pb2+ at the single channel level.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0237-6261
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
39-49
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:articleTitle |
Single-channel analysis of Pb2+ modified steady-state Na-conductance in snail neurons.
|
| pubmed:affiliation |
Department of General Physiology of Nervous System, A.A. Bogomoletz Institute of Physiology, Academy of Sciences of the Ukrainian S.S.R.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|