| pubmed-article:16685081 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16685081 | lifeskim:mentions | umls-concept:C0025927 | lld:lifeskim |
| pubmed-article:16685081 | lifeskim:mentions | umls-concept:C0201950 | lld:lifeskim |
| pubmed-article:16685081 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:16685081 | lifeskim:mentions | umls-concept:C0683224 | lld:lifeskim |
| pubmed-article:16685081 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:16685081 | lifeskim:mentions | umls-concept:C0428466 | lld:lifeskim |
| pubmed-article:16685081 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:16685081 | lifeskim:mentions | umls-concept:C2828360 | lld:lifeskim |
| pubmed-article:16685081 | lifeskim:mentions | umls-concept:C0065055 | lld:lifeskim |
| pubmed-article:16685081 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16685081 | pubmed:dateCreated | 2006-8-2 | lld:pubmed |
| pubmed-article:16685081 | pubmed:abstractText | To identify additional loci that influence lipoprotein cholesterol levels, we performed quantitative trait locus (QTL) mapping in offspring of PERA/EiJxI/LnJ and PERA/EiJxDBA/2J intercrosses and in a combined data set from both crosses after 8 weeks of consumption of a high fat-diet. Most QTLs identified were concordant with homologous chromosomal regions that were associated with lipoprotein levels in human studies. We detected significant new loci for HDL cholesterol levels on chromosome (Chr) 5 (Hdlq34) and for non-HDL cholesterol levels on Chrs 15 (Nhdlq9) and 16 (Nhdlq10). In addition, the analysis of combined data sets identified a QTL for HDL cholesterol on Chr 17 that was shared between both crosses; lower HDL cholesterol levels were conferred by strain PERA. This QTL colocalized with a shared QTL for cholesterol gallstone formation detected in the same crosses. Haplotype analysis narrowed this QTL, and sequencing of the candidate genes Abcg5 and Abcg8 confirmed shared alleles in strains I/LnJ and DBA/2J that differed from the alleles in strain PERA/EiJ. In conclusion, our analysis furthers the knowledge of genetic determinants of lipoprotein cholesterol levels in inbred mice and substantiates the hypothesis that polymorphisms of Abcg5/Abcg8 contribute to individual variation in both plasma HDL cholesterol levels and susceptibility to cholesterol gallstone formation. | lld:pubmed |
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| pubmed-article:16685081 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16685081 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16685081 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16685081 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16685081 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16685081 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16685081 | pubmed:issn | 0022-2275 | lld:pubmed |
| pubmed-article:16685081 | pubmed:author | pubmed-author:PaigenBeverly... | lld:pubmed |
| pubmed-article:16685081 | pubmed:author | pubmed-author:MössnerJoachi... | lld:pubmed |
| pubmed-article:16685081 | pubmed:author | pubmed-author:WittenburgHen... | lld:pubmed |
| pubmed-article:16685081 | pubmed:author | pubmed-author:ChurchillGary... | lld:pubmed |
| pubmed-article:16685081 | pubmed:author | pubmed-author:LiRenhuaR | lld:pubmed |
| pubmed-article:16685081 | pubmed:author | pubmed-author:CareyMartin... | lld:pubmed |
| pubmed-article:16685081 | pubmed:author | pubmed-author:LyonsMalcolm... | lld:pubmed |
| pubmed-article:16685081 | pubmed:author | pubmed-author:WangXiaosongX | lld:pubmed |
| pubmed-article:16685081 | pubmed:author | pubmed-author:KurtzUlrikeU | lld:pubmed |
| pubmed-article:16685081 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16685081 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:16685081 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16685081 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16685081 | pubmed:pagination | 1780-90 | lld:pubmed |
| pubmed-article:16685081 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:16685081 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16685081 | pubmed:articleTitle | QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains. | lld:pubmed |
| pubmed-article:16685081 | pubmed:affiliation | The Jackson Laboratory, Bar Harbor, ME, USA. henning.wittenburg@medizin.uni-leipzig.de | lld:pubmed |
| pubmed-article:16685081 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16685081 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16685081 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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