Source:http://linkedlifedata.com/resource/pubmed/id/16685081
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2006-8-2
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| pubmed:abstractText |
To identify additional loci that influence lipoprotein cholesterol levels, we performed quantitative trait locus (QTL) mapping in offspring of PERA/EiJxI/LnJ and PERA/EiJxDBA/2J intercrosses and in a combined data set from both crosses after 8 weeks of consumption of a high fat-diet. Most QTLs identified were concordant with homologous chromosomal regions that were associated with lipoprotein levels in human studies. We detected significant new loci for HDL cholesterol levels on chromosome (Chr) 5 (Hdlq34) and for non-HDL cholesterol levels on Chrs 15 (Nhdlq9) and 16 (Nhdlq10). In addition, the analysis of combined data sets identified a QTL for HDL cholesterol on Chr 17 that was shared between both crosses; lower HDL cholesterol levels were conferred by strain PERA. This QTL colocalized with a shared QTL for cholesterol gallstone formation detected in the same crosses. Haplotype analysis narrowed this QTL, and sequencing of the candidate genes Abcg5 and Abcg8 confirmed shared alleles in strains I/LnJ and DBA/2J that differed from the alleles in strain PERA/EiJ. In conclusion, our analysis furthers the knowledge of genetic determinants of lipoprotein cholesterol levels in inbred mice and substantiates the hypothesis that polymorphisms of Abcg5/Abcg8 contribute to individual variation in both plasma HDL cholesterol levels and susceptibility to cholesterol gallstone formation.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0022-2275
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
47
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1780-90
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:16685081-Alleles,
pubmed-meshheading:16685081-Animals,
pubmed-meshheading:16685081-Cholesterol,
pubmed-meshheading:16685081-Cholesterol, HDL,
pubmed-meshheading:16685081-Chromosome Mapping,
pubmed-meshheading:16685081-Chromosomes, Mammalian,
pubmed-meshheading:16685081-Crosses, Genetic,
pubmed-meshheading:16685081-Female,
pubmed-meshheading:16685081-Genetic Linkage,
pubmed-meshheading:16685081-Genotype,
pubmed-meshheading:16685081-Haplotypes,
pubmed-meshheading:16685081-Lipoproteins,
pubmed-meshheading:16685081-Male,
pubmed-meshheading:16685081-Mice,
pubmed-meshheading:16685081-Mice, Inbred DBA,
pubmed-meshheading:16685081-Mice, Inbred Strains,
pubmed-meshheading:16685081-Phenotype,
pubmed-meshheading:16685081-Quantitative Trait Loci,
pubmed-meshheading:16685081-Regression Analysis,
pubmed-meshheading:16685081-Sequence Analysis, DNA
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| pubmed:year |
2006
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| pubmed:articleTitle |
QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains.
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| pubmed:affiliation |
The Jackson Laboratory, Bar Harbor, ME, USA. henning.wittenburg@medizin.uni-leipzig.de
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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