Linked Life Data

16684804

Source:http://linkedlifedata.com/resource/pubmed/id/16684804

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-8-17
pubmed:abstractText
Treatment with vanadium, a representative of a class of antidiabetic compounds, alleviates diabetic hyperglycemia and hyperlipidemia. Oral administration of vanadium compounds in animal models and humans does not cause clinical symptoms of hypoglycemia, a common problem for diabetic patients with insulin treatment. Gene expression, using Affymetrix arrays, was examined in muscle from streptozotocin-induced diabetic and normal rats in the presence or absence of oral vanadyl sulfate treatment. This treatment affected normal rats differently from diabetic rats, as demonstrated by two-way ANOVA of the full array data. Diabetes altered the expression of 133 genes, and the expression of 30% of these genes dysregulated in diabetes was normalized by vanadyl sulfate treatment. For those genes, the ratio of expression in normal animals to the expression in diabetic animals showed a strong negative correlation with the ratio of expression in diabetic animals to the expression in diabetic animals treated with vanadyl sulfate (P = -0.85). The genes identified belong to six major metabolic functional groups: lipid metabolism, oxidative stress, muscle structure, protein breakdown and biosynthesis, the complement system, and signal transduction. The identification of oxidative stress genes, coupled with the known oxidative chemistry of vanadium, implicates reactive oxygen species in the action of this class of compounds. These results imply that early transition metals or compounds formed from their chemical interactions with other metabolites may act as general transcription modulators, a role not usually associated with this class of compounds.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1531-2267
pubmed:author
pubmed:issnType
Electronic
pubmed:day
16
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
192-201
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:16684804-Administration, Oral, pubmed-meshheading:16684804-Analysis of Variance, pubmed-meshheading:16684804-Animals, pubmed-meshheading:16684804-Blood Glucose, pubmed-meshheading:16684804-Cholesterol, pubmed-meshheading:16684804-Diabetes Mellitus, Experimental, pubmed-meshheading:16684804-Fatty Acids, Nonesterified, pubmed-meshheading:16684804-Gene Expression, pubmed-meshheading:16684804-Hyperglycemia, pubmed-meshheading:16684804-Hypoglycemic Agents, pubmed-meshheading:16684804-Lipid Metabolism, pubmed-meshheading:16684804-Male, pubmed-meshheading:16684804-Muscle, Skeletal, pubmed-meshheading:16684804-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:16684804-Oxidative Stress, pubmed-meshheading:16684804-Rats, pubmed-meshheading:16684804-Rats, Wistar, pubmed-meshheading:16684804-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:16684804-Signal Transduction, pubmed-meshheading:16684804-Triglycerides, pubmed-meshheading:16684804-Vanadium Compounds
pubmed:year
2006
pubmed:articleTitle
Diabetes-altered gene expression in rat skeletal muscle corrected by oral administration of vanadyl sulfate.
pubmed:affiliation
Department of Biochemistry, School of Medicine and Biomedical Sciences, The State University of New York (SUNY) at Buffalo, Buffalo, New York 14214, USA. gwillsky@buffalo.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural