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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-6-13
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pubmed:abstractText |
Ebola virus causes a hemorrhagic fever syndrome that is associated with high mortality in humans. In the absence of effective therapies for Ebola virus infection, the development of a vaccine becomes an important strategy to contain outbreaks. Immunization with DNA and/or replication-defective adenoviral vectors (rAd) encoding the Ebola glycoprotein (GP) and nucleoprotein (NP) has been previously shown to confer specific protective immunity in nonhuman primates. GP can exert cytopathic effects on transfected cells in vitro, and multiple GP forms have been identified in nature, raising the question of which would be optimal for a human vaccine.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-10202932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-10932225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-10950971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-11112476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-11117750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-11222689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-11238859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-12904795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-14633608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-15140961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-15580728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-15596847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-15795265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-15937495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-16254351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-8553543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-8627650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-8788172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-8793545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-8800795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-9054520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-9427604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-9658086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-9741429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16683867-9820501
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1549-1676
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pubmed:author |
pubmed-author:CustersJerome H H VJH,
pubmed-author:GeisbertJoan BJB,
pubmed-author:GeisbertThomas WTW,
pubmed-author:GoudsmitJaapJ,
pubmed-author:JahrlingPeter BPB,
pubmed-author:KoupRichard ARA,
pubmed-author:LamoreauxLaurieL,
pubmed-author:LingXuX,
pubmed-author:NabelGary JGJ,
pubmed-author:PauMaria GMG,
pubmed-author:PopernackPaul MPM,
pubmed-author:RoedererMarioM,
pubmed-author:ShedlockDevon JDJ,
pubmed-author:SullivanNancy JNJ,
pubmed-author:YangZhi-YongZY
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e177
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16683867-Adenoviridae,
pubmed-meshheading:16683867-Animals,
pubmed-meshheading:16683867-Cell Line,
pubmed-meshheading:16683867-Dose-Response Relationship, Immunologic,
pubmed-meshheading:16683867-Ebola Vaccines,
pubmed-meshheading:16683867-Ebolavirus,
pubmed-meshheading:16683867-Genetic Vectors,
pubmed-meshheading:16683867-Hemorrhagic Fever, Ebola,
pubmed-meshheading:16683867-Humans,
pubmed-meshheading:16683867-Macaca fascicularis,
pubmed-meshheading:16683867-Mutation,
pubmed-meshheading:16683867-Nucleoproteins,
pubmed-meshheading:16683867-Transfection,
pubmed-meshheading:16683867-Vaccination,
pubmed-meshheading:16683867-Vaccines, DNA,
pubmed-meshheading:16683867-Viral Envelope Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs.
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pubmed:affiliation |
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Intramural
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