16683270

Source:http://linkedlifedata.com/resource/pubmed/id/16683270

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017262, umls-concept:C0185117, umls-concept:C0287829, umls-concept:C0334227, umls-concept:C0376358, umls-concept:C1523116, umls-concept:C2911684
pubmed:issue	11
pubmed:dateCreated	2006-7-3
pubmed:abstractText	Fibroblast growth factor 8 (FGF8) is over-expressed in prostate cancer (CaP) correlating with high-grade disease and reduced survival. The role of acetylation in transcriptional regulation of FGF8 was investigated using the histone deacetylase (HDAC) inhibitor Trichostatin A (TSA).
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8101368
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Chromatin, http://linkedlifedata.com/resource/pubmed/chemical/DNA, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/FGF8 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 8, http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Hydroxamic Acids, http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B, http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases, http://linkedlifedata.com/resource/pubmed/chemical/RELA protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor RelA, http://linkedlifedata.com/resource/pubmed/chemical/trichostatin A
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0270-4137
pubmed:author	pubmed-author:ArmstrongKellyK, pubmed-author:LeungHing YHY, pubmed-author:RobsonCraig NCN
pubmed:copyrightInfo	(c) 2006 Wiley-Liss, Inc.
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	66
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1223-34
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:16683270-Acetylation, pubmed-meshheading:16683270-Base Sequence, pubmed-meshheading:16683270-Binding Sites, pubmed-meshheading:16683270-Blotting, Western, pubmed-meshheading:16683270-Cell Line, Tumor, pubmed-meshheading:16683270-Chromatin, pubmed-meshheading:16683270-DNA, pubmed-meshheading:16683270-Enzyme Inhibitors, pubmed-meshheading:16683270-Fibroblast Growth Factor 8, pubmed-meshheading:16683270-Gene Expression Regulation, Neoplastic, pubmed-meshheading:16683270-Histone Deacetylase Inhibitors, pubmed-meshheading:16683270-Humans, pubmed-meshheading:16683270-Hydroxamic Acids, pubmed-meshheading:16683270-Immunosorbent Techniques, pubmed-meshheading:16683270-Male, pubmed-meshheading:16683270-Molecular Sequence Data, pubmed-meshheading:16683270-NF-kappa B, pubmed-meshheading:16683270-Phosphatidylinositol 3-Kinases, pubmed-meshheading:16683270-Polymerase Chain Reaction, pubmed-meshheading:16683270-Promoter Regions, Genetic, pubmed-meshheading:16683270-Prostatic Neoplasms, pubmed-meshheading:16683270-Recombinant Fusion Proteins, pubmed-meshheading:16683270-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:16683270-Transcription, Genetic, pubmed-meshheading:16683270-Transcription Factor RelA, pubmed-meshheading:16683270-Transfection, pubmed-meshheading:16683270-Up-Regulation
pubmed:year	2006
pubmed:articleTitle	NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells.
pubmed:affiliation	Urology Research Group, Northern Institute for Cancer Research, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne, United Kingdom.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't