Source:http://linkedlifedata.com/resource/pubmed/id/16682508
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2006-5-9
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| pubmed:abstractText |
We have previously reported that high grade and non-high grade ductal carcinoma in situ (DCIS) of the breast can be subdivided into 3 cell origin subtypes (luminal, basal/stem, and null), and that high grade DCIS is more frequently associated with basal/stem cell subtypes compared to non-high grade DCIS. Here we refine the relationships between these 3 subtypes and the expression patterns of estrogen receptor-alpha (ER-alpha), progesterone receptor (PR), HER-2/neu, and epidermal growth factor receptor (ERFR) in 53 cases of non-high grade and 46 cases of high nuclear grade DCIS. Using a panel of antibodies to ER-alpha, PR, HER-2/neu, and EGFR, along with cytokeratin (CK) markers (CK5/6, CK8, CK14, CK17, and CK18), we found that all 3 cell origin subtypes can express ER-alpha and PR, and their expression is higher in non-high grade DCIS than in high grade DCIS; the expression of HER-2/neu is associated with luminal subtype only in non-high grade DCIS, but can be seen in all 3 subtypes in high grade DCIS; the expression of EGFR is low and is present only in luminal cell subtypes in both high and non-high grade DCIS. Basal/ stem cell and null cell subtypes occur in younger patients in non-high grade DCIS compared to high grade DCIS. In conclusion, the expression patterns of ER-alpha, PR, HER-2/neu, and EGFR are markedly different in different cell origin subtypes of both high grade and non-high grade DCIS, suggesting that cell origin subtypes as well as nuclear grade contribute to the biological and molecular heterogeneity of DCIS.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins v-erbB,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0091-7370
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
36
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
137-43
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:16682508-Adult,
pubmed-meshheading:16682508-Breast Neoplasms,
pubmed-meshheading:16682508-Carcinoma, Intraductal, Noninfiltrating,
pubmed-meshheading:16682508-Chi-Square Distribution,
pubmed-meshheading:16682508-Estrogen Receptor alpha,
pubmed-meshheading:16682508-Female,
pubmed-meshheading:16682508-Humans,
pubmed-meshheading:16682508-Middle Aged,
pubmed-meshheading:16682508-Neoplasm Proteins,
pubmed-meshheading:16682508-Oncogene Proteins v-erbB,
pubmed-meshheading:16682508-Receptor, Epidermal Growth Factor,
pubmed-meshheading:16682508-Receptors, Progesterone
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| pubmed:year |
2006
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| pubmed:articleTitle |
Expression patterns of ER-alpha, PR, HER-2/neu, and EGFR in different cell origin subtypes of high grade and non-high grade ductal carcinoma in situ.
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| pubmed:affiliation |
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 626, Rochester, New York 14642 USA. ping_tang@urmc.rochester.edu
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| pubmed:publicationType |
Journal Article
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