Source:http://linkedlifedata.com/resource/pubmed/id/16682194
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
14
|
| pubmed:dateCreated |
2006-6-5
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| pubmed:abstractText |
A series of N-{1-[(3-thioxo-5,6-dihydroimidazo[2,1-c][1,2,4]thiadiazol-7-ylthio)thiocarbonyl]-2-imidazolidene}arylsulfonamides (2a-z) was obtained by reacting 6,7-dihydro-1H-imidazo[2,1-c][1,2,4]thiadiazol-3-thione (1) with arylsulfonyl chlorides. The relationships between structure and anti-tumor activity revealed that compound 2o with p-Cl substituent at the phenyl ring was most active (-log GI50>8.00, -log TGI=7.66) and was found to exhibit high selectivity toward the leukemia CCRF-CEM cell line (Deltaf=3.08 and 3.31, respectively).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0960-894X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3663-7
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16682194-Antineoplastic Agents,
pubmed-meshheading:16682194-Cell Line, Tumor,
pubmed-meshheading:16682194-Humans,
pubmed-meshheading:16682194-Inhibitory Concentration 50,
pubmed-meshheading:16682194-Leukemia, Lymphoid,
pubmed-meshheading:16682194-Structure-Activity Relationship,
pubmed-meshheading:16682194-Sulfonamides,
pubmed-meshheading:16682194-Thiadiazoles
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Synthesis and in vitro anti-tumor activity of N-{1-[(3-thioxo-5,6-dihydroimidazo[2,1-c][1,2,4]thiadiazol-7-ylthio)thiocarbonyl]-2-imidazolidene}arylsulfonamides.
|
| pubmed:affiliation |
Department of Chemical Technology of Drugs, Medical University of Gda?sk, 80-416 Gda?sk, Poland. saczew@amg.gda.pl
|
| pubmed:publicationType |
Journal Article
|