Source:http://linkedlifedata.com/resource/pubmed/id/16682020
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-3
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| pubmed:dateCreated |
2006-5-22
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| pubmed:abstractText |
The temporal effect of (R)-alpha-methylhistamine on epithelial cell proliferation throughout the rat gastrointestinal tract was investigated. (R)-alpha-methylhistamine was administered at 100 mg/kg orally and the rats were sacrificed 1, 24, 48, 72 and 144 h later. All the animals received 5-bromo-2'-deoxyuridine, (BrdU), 200 mg/kg i.p., 2 h before sacrifice. Gastrointestinal tissue was processed for histology and immunohistochemistry. (R)-alpha-methylhistamine caused a progressive increase in mucosal thickness of gastric fundus, distal small intestine and distal colon. Statistically significant differences from control values were found between 48 and 72 h after (R)-alpha-methylhistamine. (R)-alpha-methylhistamine significantly increased the number of BrdU-positive cells in the gastric fundus and antrum, intermediate and distal small intestine and distal colon. Peak effects were observed between 1 and 24 h after (R)-alpha-methylhistamine administration. Proliferating cell number and mucosal thickness were comparable to those of control rats at 144 h. (R)-alpha-methylhistamine exerts a long lasting growth-promoting effect on the stomach, distal small intestine and distal colon. Present data support a role of histamine H(3) receptors in the normal regulation of cell cycle in epithelial tissue.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0014-2999
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
24
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| pubmed:volume |
538
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
141-7
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| pubmed:meshHeading |
pubmed-meshheading:16682020-Analysis of Variance,
pubmed-meshheading:16682020-Animals,
pubmed-meshheading:16682020-Cell Proliferation,
pubmed-meshheading:16682020-Colon,
pubmed-meshheading:16682020-Epithelial Cells,
pubmed-meshheading:16682020-Gastrointestinal Tract,
pubmed-meshheading:16682020-Histamine Agonists,
pubmed-meshheading:16682020-Ileum,
pubmed-meshheading:16682020-Intestinal Mucosa,
pubmed-meshheading:16682020-Male,
pubmed-meshheading:16682020-Methylhistamines,
pubmed-meshheading:16682020-Rats,
pubmed-meshheading:16682020-Rats, Wistar,
pubmed-meshheading:16682020-Receptors, Histamine H3,
pubmed-meshheading:16682020-Stomach,
pubmed-meshheading:16682020-Time Factors
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Epithelial cell proliferation is promoted by the histamine H(3) receptor agonist (R)-alpha-methylhistamine throughout the rat gastrointestinal tract.
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| pubmed:affiliation |
Department of Human Anatomy, Pharmacology and Forensic Medicine, University of Parma, 43100 Parma, Italy.
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| pubmed:publicationType |
Journal Article
|